Imperial College London

DrBeatrizJimenez

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

NMR Manager
 
 
 
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Contact

 

+44 (0)20 7594 2441b.jimenez Website

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

I define myself as an NMR (Nuclear Magnetic Resonance) spectroscopist and throughout my career, I have worked in a variety of fields with NMR being a constant theme. I started my career as inorganic chemist working on the characterisation of the metal centre of metaloproteins and soon after developed a strong interest structural biology and the characterisation of protein function. To solve the solution structure of a protein it is necessary to acquire multidimensional NMR spectra. The experiments can be complicated and require detailed knowledge of different NMR parameters and how they can be manipulated to solve the structure of a protein. This led me to work in NMR pulse sequence development- in order to be able to optimise the experiments myself- and obtain more information about my protein samples.

As I have always been interested in how NMR can be used to answer biologically relevant questions, I soon became interested in Metabonomics and have now been working in the field for about six years. The NMR knowledge required to obtain the necessary data is relatively basic but provides detailed information about the biochemistry of a biological system that can be used for diagnostics, prognostics and for monitoring drug metabolism (amongst many other applications).

I have now been working at Imperial College for two years where I in charge of the NMR section of the Clinical Phenotyping Center. It is a very challenging and exciting role that aims to bring together medicine and research.

Our focus is applying NMR-based metabolomics to the diagnosis and prognosis of disease. To do so we have recently installed three NMR spectrometers in a hospital setting (Saint Mary's) where scientists and clinicians work closely to make this project a reality.

Publications

Journals

Sands C, Wolfer A, DS Correia G, et al., 2019, The nPYc-Toolbox, a Python module for the pre-processing, quality-control, and analysis of metabolic profiling datasets, Bioinformatics, Vol:35, ISSN:1367-4803, Pages:5359-5360

Whiley L, Chekmeneva E, Berry DJ, et al., 2019, Systematic isolation and structure elucidation of urinary metabolites optimized for the analytical-scale molecular profiling laboratory, Analytical Chemistry, Vol:91, ISSN:0003-2700, Pages:8873-8882

Rodriguez-Martinez A, Ayala R, Posma JM, et al., 2019, pJRES Binning Algorithm (JBA): a new method to facilitate the recovery of metabolic information from pJRES 1H NMR spectra, Bioinformatics, Vol:35, ISSN:1367-4803, Pages:1916-1922

Harbaum L, Ghataorhe P, Wharton J, et al., 2019, Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension, Thorax, Vol:74, ISSN:1468-3296, Pages:380-389

Gafson AR, Thorne T, McKechnie CIJ, et al., 2018, Lipoprotein markers associated with disability from multiple sclerosis, Scientific Reports, Vol:8, ISSN:2045-2322

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