Imperial College London
Alternate

DrBirgitLeitinger

Faculty of Medicine, National Heart & Lung Institute

Reader in Matrix Receptor Signalling
 
 
 
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Contact

 

+44 (0)20 7594 1591b.leitinger Website

 
 
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Location

 

115Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gao:2016:10.1016/j.cell.2016.06.009,
author = {Gao, H and Chakraborty, G and Zhang, Z and Akalay, I and Gadiya, M and Gao, Y and Sinha, S and Hu, J and Jiang, C and Akram, M and Brogi, E and Leitinger, B and Giancotti, FG},
doi = {10.1016/j.cell.2016.06.009},
journal = {Cell},
pages = {47--62},
title = {Multi-organ site metastatic reactivation mediated by non-canonical discoidin domain receptor 1 signaling},
url = {http://dx.doi.org/10.1016/j.cell.2016.06.009},
volume = {166},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator ofmetastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagenreceptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, toPKC. The latter kinase phosphorylates and activates JAK2, leading to theactivation of STAT3. This non-canonical mechanism of signaling induces theexpression of SOX2 and NANOG, sustains the manifestation of cancer stem celltraits, and drives metastatic reactivation in the lung, bone, and brain. Bioinformaticanalyses and pathological studies corroborate the clinical relevance of thesefindings. We conclude that non-canonical DDR1 signaling enables breast cancercells to exploit the ubiquitous interstitial matrix component collagen I to undergometastatic reactivation in multiple target organs.
AU  - Gao,H
AU  - Chakraborty,G
AU  - Zhang,Z
AU  - Akalay,I
AU  - Gadiya,M
AU  - Gao,Y
AU  - Sinha,S
AU  - Hu,J
AU  - Jiang,C
AU  - Akram,M
AU  - Brogi,E
AU  - Leitinger,B
AU  - Giancotti,FG
DO  - 10.1016/j.cell.2016.06.009
EP  - 62
PY  - 2016///
SN  - 0092-8674
SP  - 47
TI  - Multi-organ site metastatic reactivation mediated by non-canonical discoidin domain receptor 1 signaling
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2016.06.009
UR  - https://www.sciencedirect.com/science/article/pii/S0092867416307383?via%3Dihub
UR  - http://hdl.handle.net/10044/1/34241
VL  - 166
ER  -
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