Imperial College London
Alternate

DrBirgitLeitinger

Faculty of Medicine, National Heart & Lung Institute

Reader in Matrix Receptor Signalling
 
 
 
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Contact

 

+44 (0)20 7594 1591b.leitinger Website

 
 
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Location

 

115Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Leitinger:2016:10.1007/978-1-4939-6383-6_1,
author = {Leitinger, B},
booktitle = {Discoidin Domain Receptors in Health and Disease},
doi = {10.1007/978-1-4939-6383-6_1},
pages = {3--21},
title = {DDRs: Binding properties, cell adhesion and modulation of integrin function},
url = {http://dx.doi.org/10.1007/978-1-4939-6383-6_1},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The discoidin domain receptors are a subfamily of receptor tyrosine kinases that consist of two members, DDR1 and DDR2. These closely related proteins are characterized by the presence of a discoidin homology (DS) domain in their extracellular regions, as well as a domain of similar structure, the DS-like domain. The DDRs function as transmembrane collagen receptors and are thus at the interface of receptor tyrosine kinases and integrins, the main receptors for extracellular matrix molecules. Both DDRs are activated by a number of different collagen types, with which they interact through a conserved ligand-binding trench that is contained in their DS domains. The DDRs have overlapping functions with integrins and can modulate cell adhesion and cell migration. Depending on the cellular context, DDR-induced signalling can impact integrin-mediated signalling in positive or negative ways. Here, the DDRs are discussed in terms of their molecular basis of collagen recognition, their roles in cell adhesion and migration and their ability to modulate integrin function.
AU  - Leitinger,B
DO  - 10.1007/978-1-4939-6383-6_1
EP  - 21
PY  - 2016///
SN  - 9781493963812
SP  - 3
TI  - DDRs: Binding properties, cell adhesion and modulation of integrin function
T1  - Discoidin Domain Receptors in Health and Disease
UR  - http://dx.doi.org/10.1007/978-1-4939-6383-6_1
ER  -
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