Imperial College London
Alternate

DrBirgitLeitinger

Faculty of Medicine, National Heart & Lung Institute

Reader in Matrix Receptor Signalling
 
 
 
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Contact

 

+44 (0)20 7594 1591b.leitinger Website

 
 
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Location

 

115Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gorlitz:2017:10.3390/photonics4030040,
author = {Gorlitz, F and Corcoran, DS and Garcia, Castano EA and Leitinger, B and Neil, MAA and Dunsby, CW and French, PMW},
doi = {10.3390/photonics4030040},
journal = {Photonics},
title = {Mapping molecular function to biological nanostructure: combining structured illumination microscopy with fluorescence lifetime imaging (SIM+FLIM)},
url = {http://dx.doi.org/10.3390/photonics4030040},
volume = {4},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We present a new microscope integrating super-resolved imaging using structured illumination microscopy (SIM) with wide-field optically sectioned fluorescence lifetime imaging (FLIM) to provide optical mapping of molecular function and its correlation with biological nanostructure below the conventional diffraction limit. We illustrate this SIM + FLIM capability to map FRET readouts applied to the aggregation of discoidin domain receptor 1 (DDR1) in Cos 7 cells following ligand stimulation and to the compaction of DNA during the cell cycle.
AU  - Gorlitz,F
AU  - Corcoran,DS
AU  - Garcia,Castano EA
AU  - Leitinger,B
AU  - Neil,MAA
AU  - Dunsby,CW
AU  - French,PMW
DO  - 10.3390/photonics4030040
PY  - 2017///
SN  - 2304-6732
TI  - Mapping molecular function to biological nanostructure: combining structured illumination microscopy with fluorescence lifetime imaging (SIM+FLIM)
T2  - Photonics
UR  - http://dx.doi.org/10.3390/photonics4030040
UR  - http://hdl.handle.net/10044/1/49839
VL  - 4
ER  -
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