The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., 2020, Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing, Nature Communications, Vol:11, ISSN:2041-1723
et al., 2020, JASPAR 2020: update of the open-access database of transcription factor binding profiles., Nucleic Acids Res, Vol:48, Pages:D87-D92
et al., 2020, Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks, Molecular Psychiatry, Vol:25, ISSN:1359-4184, Pages:6-18
Tan G, Polychronopoulos D, Lenhard B, 2019, CNEr: A toolkit for exploring extreme noncoding conservation, Plos Computational Biology, Vol:15
Nash AJ, Lenhard B, 2019, A novel measure of non-coding genome conservation identifies genomic regulatory blocks within primates, Bioinformatics, Vol:35, ISSN:1367-4803, Pages:2354-2361