Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology



+44 (0)20 3313 8353b.lenhard Website




Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318




230ICTEM buildingHammersmith Campus





The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:

  • Structure and function of gene promoters
  • Function and genomic distribution of gene regulatory elements
  • Function of transcription factors
  • Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
  • Association of different modes of regulation with epigenetic marks and their inheritance

Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.



Baranasic D, Hortenhuber M, Balwierz PJ, et al., 2022, Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements, Nature Genetics, ISSN:1061-4036

Jobbins AM, Haberman N, Artigas N, et al., 2022, Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:3379-3393

McAllan L, Baranasic D, VillicaƱa S, et al., 2021, Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

Castro-Mondragon JA, Riudavets-Puig R, Rauluseviciute I, et al., 2021, JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:D165-D173

Lopez-Perez AR, Balwierz PJ, Lenhard B, et al., 2021, Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics, Scientific Reports, Vol:11, ISSN:2045-2322

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