The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., 2022, Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice, Nature Metabolism, Vol:4, ISSN:2522-5812, Pages:1812-1829
et al., 2022, Chromatin jets define the properties of cohesin-driven in vivo loop extrusion, Molecular Cell, Vol:82, ISSN:1097-2765, Pages:3769-3780.e5
et al., 2022, Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements, Nature Genetics, Vol:54, ISSN:1061-4036, Pages:1037-+
et al., 2022, Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease, Nucleic Acids Research, Vol:50, ISSN:0305-1048, Pages:3379-3393
et al., 2021, Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes