Imperial College London
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ProfessorBorisLenhard

Faculty of Medicine, Institute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 7594 0911b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

6.12CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Merkenschlager:2018:10.1038/s41590-018-0184-1,
author = {Merkenschlager, M and Cuartero, S and Weiss, F and Dharmalingam, G and Guo, Y and Ing-Simmons, E and Masella, S and Robles-Rebollo, I and Xiao, X and Barozzi, I and Djeghloul, D and Amano, M and Niskanen, H and Petretto, E and Dowell, R and Tachibana, K and Kaikkonen, M and Nasmyth, K and Lenhard, B and Natoli, G and Fisher, A},
doi = {10.1038/s41590-018-0184-1},
journal = {Nature Immunology},
pages = {932--941},
title = {Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation},
url = {http://dx.doi.org/10.1038/s41590-018-0184-1},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene transcription and enhancer activity. Here we show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression. Consistent with a role for inflammatory signals in promoting myeloid differentiation of hematopoietic stem and progenitor cells (HPSCs), cohesin mutations in HSPCs led to reduced inflammatory gene expression and increased resistance to differentiation-inducing inflammatory stimuli. These findings uncover an unexpected dependence of inducible gene expression on cohesin, link cohesin with myeloid differentiation, and may help explain the prevalence of cohesin mutations in human acute myeloid leukemia.
AU  - Merkenschlager,M
AU  - Cuartero,S
AU  - Weiss,F
AU  - Dharmalingam,G
AU  - Guo,Y
AU  - Ing-Simmons,E
AU  - Masella,S
AU  - Robles-Rebollo,I
AU  - Xiao,X
AU  - Barozzi,I
AU  - Djeghloul,D
AU  - Amano,M
AU  - Niskanen,H
AU  - Petretto,E
AU  - Dowell,R
AU  - Tachibana,K
AU  - Kaikkonen,M
AU  - Nasmyth,K
AU  - Lenhard,B
AU  - Natoli,G
AU  - Fisher,A
DO  - 10.1038/s41590-018-0184-1
EP  - 941
PY  - 2018///
SN  - 1529-2908
SP  - 932
TI  - Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
T2  - Nature Immunology
UR  - http://dx.doi.org/10.1038/s41590-018-0184-1
UR  - https://www.nature.com/articles/s41590-018-0184-1
UR  - http://hdl.handle.net/10044/1/62818
VL  - 19
ER  -
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