Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gupta:2021:10.14309/ajg.0000000000001075,
author = {Gupta, S and Mullish, BH and Allegretti, JR},
doi = {10.14309/ajg.0000000000001075},
journal = {American Journal of Gastroenterology},
pages = {647--656},
title = {Fecal microbiota transplantation: the evolving risk landscape},
url = {http://dx.doi.org/10.14309/ajg.0000000000001075},
volume = {116},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fecal microbiota transplantation (FMT) has been recommended in clinical guidelines for the treatment for recurrent Clostridioides difficile infection (CDI). However, it is considered investigational by most regulatory agencies. As the adoption of FMT increased from a small group of CDI experts alone to more widespread use, there has been a corresponding increase in concern regarding potential risk. FMT is largely considered a safe procedure, though risks described range from mild gastrointestinal symptoms to serious infection. Currently, there is variability in how ‘FMT’ is characterized specifically with regards to testing approach, which, in turn, impacts the risk profile. This has been highlighted by the rare cases of multidrug-resistant organisms, Shiga toxin-producing E. coli and enteropathogenic E. coli recently reported, where these organisms were not screened. These cases have prompted additional screening mandates from the FDA, which has maintained its policy of enforcement discretion for the use of FMT for CDI not responding to standard therapy. Here, we examine the evolving risk landscape of FMT.
AU  - Gupta,S
AU  - Mullish,BH
AU  - Allegretti,JR
DO  - 10.14309/ajg.0000000000001075
EP  - 656
PY  - 2021///
SN  - 0002-9270
SP  - 647
TI  - Fecal microbiota transplantation: the evolving risk landscape
T2  - American Journal of Gastroenterology
UR  - http://dx.doi.org/10.14309/ajg.0000000000001075
UR  - https://journals.lww.com/ajg/Fulltext/2021/04000/Fecal_Microbiota_Transplantation__The_Evolving.13.aspx
UR  - http://hdl.handle.net/10044/1/85089
VL  - 116
ER  -
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