Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Michael:2020:10.1038/s41598-020-78285-3,
author = {Michael, DR and Davies, TS and Jack, AA and Masetti, G and Marchesi, JR and Wang, D and Mullish, BH and Plummer, SF},
doi = {10.1038/s41598-020-78285-3},
journal = {Scientific Reports},
title = {Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults},
url = {http://dx.doi.org/10.1038/s41598-020-78285-3},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45–65 years with BMI 25–29.9 kg/m<jats:sup>2</jats:sup> received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, <jats:italic>p</jats:italic> < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, <jats:italic>p</jats:italic> < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, <jats:italic>p</jats:italic> < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.</jats:p>
AU  - Michael,DR
AU  - Davies,TS
AU  - Jack,AA
AU  - Masetti,G
AU  - Marchesi,JR
AU  - Wang,D
AU  - Mullish,BH
AU  - Plummer,SF
DO  - 10.1038/s41598-020-78285-3
PY  - 2020///
TI  - Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-78285-3
UR  - http://hdl.handle.net/10044/1/85876
VL  - 11
ER  -
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