Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mullish:2021:10.1080/19490976.2021.1900997,
author = {Mullish, BH and Marchesi, JR and McDonald, JAK and Pass, DA and Masetti, G and Michael, DR and Plummer, S and Jack, AA and Davies, TS and Hughes, TR and Wang, D},
doi = {10.1080/19490976.2021.1900997},
journal = {Gut Microbes},
pages = {1--9},
title = {Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?},
url = {http://dx.doi.org/10.1080/19490976.2021.1900997},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections, and clinical trials of probiotics show promise in this regard in healthy adults and children. However, comparable studies are lacking in overweight/obese people, who have increased risks in particular of viral upper respiratory tract infections (URTI). This Addendum further analyses our recent placebo-controlled trial of probiotics in overweight/obese people (focused initially on weight loss) to investigate the impact of probiotics upon the occurrence of URTI symptoms. As well as undergoing loss of weight and improvement in certain metabolic parameters, study participants taking probiotics experienced a 27% reduction in URTI symptoms versus control, with those ≥45 years or BMI ≥30 kg/m2 experiencing greater reductions. This symptom reduction is apparent within 2 weeks of probiotic use. Gut microbiome diversity remained stable throughout the study in probiotic-treated participants. Our data provide support for further trials to assess the potential role of probiotics in preventing viral URTI (and possibly also COVID-19), particularly in overweight/obese people.
AU  - Mullish,BH
AU  - Marchesi,JR
AU  - McDonald,JAK
AU  - Pass,DA
AU  - Masetti,G
AU  - Michael,DR
AU  - Plummer,S
AU  - Jack,AA
AU  - Davies,TS
AU  - Hughes,TR
AU  - Wang,D
DO  - 10.1080/19490976.2021.1900997
EP  - 9
PY  - 2021///
SN  - 1949-0976
SP  - 1
TI  - Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?
T2  - Gut Microbes
UR  - http://dx.doi.org/10.1080/19490976.2021.1900997
UR  - https://www.tandfonline.com/doi/full/10.1080/19490976.2021.1900997
UR  - http://hdl.handle.net/10044/1/88427
VL  - 13
ER  -
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