Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Forlano:2022:10.3390/ijms23020662,
author = {Forlano, R and Mullish, BH and Roberts, LA and Thursz, MR and Manousou, P},
doi = {10.3390/ijms23020662},
journal = {International Journal of Molecular Sciences},
title = {The intestinal barrier and its dysfunction in patients with metabolic diseases and non-alcoholic fatty liver disease},
url = {http://dx.doi.org/10.3390/ijms23020662},
volume = {23},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Non-alcoholic fatty liver disease (NAFLD) represents an increasing cause of liver disease worldwide, mirroring the epidemics of obesity and metabolic syndrome. As there are still no licensed medications for treating the disease, there is an ongoing effort to elucidate the pathophysiology and to discover new treatment pathways. An increasing body of evidence has demonstrated a crosstalk between the gut and the liver, which plays a crucial role in the development and progression of liver disease. Among other intestinal factors, gut permeability represents an interesting factor at the interface of the gut–liver axis. In this narrative review, we summarise the evidence from human studies showing the association between increased gut permeability and NAFLD, as well as with type-2 diabetes and obesity. We also discuss the manipulation of the gut permeability as a potential therapeutical target in patients with NAFLD.
AU  - Forlano,R
AU  - Mullish,BH
AU  - Roberts,LA
AU  - Thursz,MR
AU  - Manousou,P
DO  - 10.3390/ijms23020662
PY  - 2022///
SN  - 1422-0067
TI  - The intestinal barrier and its dysfunction in patients with metabolic diseases and non-alcoholic fatty liver disease
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms23020662
UR  - http://hdl.handle.net/10044/1/94248
VL  - 23
ER  -
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