Imperial College London
Portrait Picture

Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
//

Contact

 

b.mullish

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Mullish:2023:10.3920/BM2022.0092,
author = {Mullish, BH and Michael, DR and Webberley, TS and John, D and Ramanathan, G and Plummer, SF and Wang, D and Marchesi, JR},
doi = {10.3920/BM2022.0092},
journal = {Benef Microbes},
pages = {1--14},
title = {The gastrointestinal status of healthy adults: a post hoc assessment of the impact of three distinct probiotics.},
url = {http://dx.doi.org/10.3920/BM2022.0092},
year = {2023}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is a growing awareness that supplementation with probiotic bacteria can impart beneficial effects during gastrointestinal disease, but less is known about the impact of probiotics on healthy subjects. Here, we report the outcomes of a post hoc analysis of recorded daily gastrointestinal events and bowel habits completed by healthy adults participating in a placebo-controlled, single-centre, randomised, double-blind, quadruple-arm probiotic tolerability study. Extensive screening ensured the healthy status of subjects entering the study and during a 2-week pre-intervention run-in period, a burden of gastrointestinal events (stomach pains, indigestion, acid reflux, stomach tightening, nausea and vomiting, stomach rumbling, bloating, belching and flatulence) was identified suggesting GI discomfort within the population. In the subsequent 12-week intervention period with 3 distinct probiotic formulations and a matched-placebo, reductions in the incidence rates of bloating, borborygmus, stomach pains, slow faecal transit and incomplete defecations were observed in the probiotic groups compared to the placebo. These results highlighted differing responses among the probiotic formulations tested and indicated potential anti-constipation effects. Product specific modulations in circulating interleukin-6 levels and in the composition of the gut microbiota were also detected. Together, these data suggest a role for probiotic supplementation to exert beneficial effects on the gastrointestinal functioning of healthy subjects and highlight the need for further longer-term studies in healthy populations to gain a greater understanding of the impact of probiotics.
AU  - Mullish,BH
AU  - Michael,DR
AU  - Webberley,TS
AU  - John,D
AU  - Ramanathan,G
AU  - Plummer,SF
AU  - Wang,D
AU  - Marchesi,JR
DO  - 10.3920/BM2022.0092
EP  - 14
PY  - 2023///
SP  - 1
TI  - The gastrointestinal status of healthy adults: a post hoc assessment of the impact of three distinct probiotics.
T2  - Benef Microbes
UR  - http://dx.doi.org/10.3920/BM2022.0092
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37026364
UR  - http://hdl.handle.net/10044/1/102789
ER  -
Download