169 results found
CHALLISS RAJ, WILLCOCKS AL, MULLOY B, et al., 1991, CHARACTERIZATION OF INOSITOL 1,4,5-TRISPHOSPHATE-BINDING AND INOSITOL 1,3,4,5-TETRAKISPHOSPHATE-BINDING SITES IN RAT CEREBELLUM, BIOCHEMICAL JOURNAL, Vol: 274, Pages: 861-867, ISSN: 0264-6021
ALBANO RM, PAVAO MSG, MOURAO PAS, et al., 1990, STRUCTURAL STUDIES OF A SULFATED L-GALACTAN FROM STYELA-PLICATA (TUNICATE) - ANALYSIS OF THE SMITH-DEGRADED POLYSACCHARIDE, CARBOHYDRATE RESEARCH, Vol: 208, Pages: 163-174, ISSN: 0008-6215
PAVAO MSG, MOURAO PAS, MULLOY B, 1990, STRUCTURE OF A UNIQUE SULFATED ALPHA-L-GALACTOFUCAN FROM THE TUNICATE CLAVELINA, CARBOHYDRATE RESEARCH, Vol: 208, Pages: 153-161, ISSN: 0008-6215
REDHEAD K, HILL T, MULLOY B, 1990, ANTIMICROBIAL EFFECT OF HUMAN-MILK ON BORDETELLA-PERTUSSIS, FEMS MICROBIOLOGY LETTERS, Vol: 70, Pages: 269-273, ISSN: 0378-1097
Redhead K, Hill T, Mulloy B, 1990, Antimicrobial effect of human milk on Bordetella pertussis., FEMS Microbiol Lett, Vol: 58, Pages: 269-273, ISSN: 0378-1097
It has been demonstrated that human milk, unlike bovine milk, can reduce the viability of Bordetella pertussis. This antibacterial activity was not due to the presence of antibiotics or antibodies in the human milk. Reducing the level of available iron or increasing the concentration of lysozyme in bovine milk did not induce anti-B. pertussis activity. Analysis of total fatty acids revealed that human milk contained significantly more linoleic acid than bovine milk. However, the addition of linoleic acid to bovine milk did not inhibit the growth of B. pertussis.
HOFFMAN RE, RUTHERFORD TJ, MULLOY B, et al., 1990, H-1-NMR ASSIGNMENT AND CONFORMATIONAL-ANALYSIS OF GLUCITOL - COMPARISON WITH MALTITOL, MAGNETIC RESONANCE IN CHEMISTRY, Vol: 28, Pages: 458-464, ISSN: 0749-1581
FORSTER M, JONES C, MULLOY B, 1989, NOEMOL - INTEGRATED MOLECULAR GRAPHICS AND THE SIMULATION OF NUCLEAR OVERHAUSER EFFECTS IN NMR-SPECTROSCOPY, JOURNAL OF MOLECULAR GRAPHICS, Vol: 7, Pages: 196-&, ISSN: 0263-7855
FORSTER MJ, JORDAN M, JONES C, et al., 1989, NOEMOL - INTEGRATED MOLECULAR GRAPHICS AND THE SIMULATION OF NUCLEAR OVERHAUSER EFFECTS IN NMR-SPECTROSCOPY, Publisher: BUTTERWORTH-HEINEMANN, Pages: 182-182, ISSN: 0263-7855
BARROWCLIFFE TW, MULLOY B, JOHNSON EA, et al., 1989, THE ANTICOAGULANT ACTIVITY OF HEPARIN - MEASUREMENT AND RELATIONSHIP TO CHEMICAL-STRUCTURE, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 7, Pages: 217-226, ISSN: 0731-7085
MULLOY B, FRENKIEL TA, DAVIES DB, 1988, LONG-RANGE CARBON PROTON COUPLING-CONSTANTS - APPLICATION TO CONFORMATIONAL STUDIES OF OLIGOSACCHARIDES, CARBOHYDRATE RESEARCH, Vol: 184, Pages: 39-46, ISSN: 0008-6215
MULLOY B, JOHNSON EA, 1987, ASSIGNMENT OF THE H-1-NMR SPECTRA OF HEPARIN AND HEPARAN-SULFATE, CARBOHYDRATE RESEARCH, Vol: 170, Pages: 151-165, ISSN: 0008-6215
JONES C, MULLOY B, WILSON A, et al., 1985, STRUCTURE OF THE CAPSULAR POLYSACCHARIDE FROM STREPTOCOCCUS-PNEUMONIAE TYPE-9, JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Pages: 1665-1673, ISSN: 0300-922X
CASU B, JOHNSON EA, MANTOVANI M, et al., 1983, CORRELATION BETWEEN STRUCTURE, FAT-CLEARING AND ANTICOAGULANT PROPERTIES OF HEPARINS AND HEPARAN SULFATES, ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, Vol: 33-1, Pages: 135-142, ISSN: 0004-4172
Casu B, Johnson EA, Mantovani M, et al., 1983, Correlation between structure, fat-clearing and anticoagulant properties of heparins and heparan sulphates., Arzneimittelforschung, Vol: 33, Pages: 135-142, ISSN: 0004-4172
Heparins and heparan sulphates from different organs, of high purity by accepted criteria, were characterized by chemical and physical (including electrophoretic and 13C-NMR spectroscopic) methods. The fat-clearing activity of these preparations was shown to be correlated with their content of the trisulphated disaccharide units I2S-ANS,6S (L-iduronic acid 2-O-sulphate-N-sulphated D-glucosamino 6-O sulphate). Species with low anti-lipemic activity contained significant proportions (greater than or equal to 30%) of nonsulphated uronic acids (especially D-glucuronic acid), and of D-glucosamino residues undersulphated at C-6, these latter residues being partially N-acetylated. Heparins from beef lung and sheep mucosa, predominantly consisting of trisulphated disaccharide units, displayed consistently higher antilipemic activity than the more heterogeneous pig mucosal heparins. The anticoagulant activity (as determined by the U.S.P., APTT and anti-Xa tests) was not a simple function of the measured physicochemical parameters. Trends were confirmed for pig mucosal heparins being more anticoagulant than beef lung preparations, and low molecular weight (usually undersulphated) species being more active in the anti-Xa test than in the U.S.P. and APTT tests.
MULLOY B, JOHNSON EA, 1980, GEL-PERMEATION CHROMATOGRAPHY OF HEPARINS, THROMBOSIS AND HAEMOSTASIS, Vol: 43, Pages: 192-193, ISSN: 0340-6245
Johnson EA, Mulloy B, 1976, Simple metachromatic assay methods for heparin and protamine., J Pharm Pharmacol, Vol: 28, Pages: 836-837, ISSN: 0022-3573
Johnson EA, Mulloy B, 1976, The molecular-weight range of mucosal-heparin preparations., Carbohydr Res, Vol: 51, Pages: 119-127, ISSN: 0008-6215
A recently reported method describes the determination of the molecular-weight range of heparins by using an electrofocusing procedure to isolate individual molecular species. Commercially available heparins were fractionated on a column of polyacrylamide-agarose gel to give fractions whose molecular weights were estimated by viscometry. Fractions with mutually exclusive molecllar-weight ranges gave an appreciable number of common bands when subjected to the electrofocusing procedure; therefore, each of these bands cannot be formed from a single molecular species of heparin. Other mucopolysaccharides also gave band sequences indistinguishable from those of heparin; they differed in position and intensity with different ampholyte batches, and probably arose from individual molecular species of the ampholyte rather than the mucopolysaccharide. The molecular-weight range of the heparin was observed to be broader than that usually reported.
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