Imperial College London
Alternate

DrBrianRobertson

Faculty of Medicine, Department of Infectious Disease

Reader in Systems Microbiology
 
 
 
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Contact

 

b.robertson

 
 
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Location

 

3.41Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alzahabi:2020:10.1042/ETLS20190154,
author = {Alzahabi, KH and Usmani, O and Georgiou, TK and Ryan, MP and Robertson, BD and Tetley, TD and Porter, AE},
doi = {10.1042/ETLS20190154},
journal = {Emerging Topics in Life Sciences},
pages = {581--600},
title = {Approaches to treating tuberculosis by encapsulating metal ions and anti-mycobacterial drugs utilizing nano- and microparticle technologies},
url = {http://dx.doi.org/10.1042/ETLS20190154},
volume = {4},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Tuberculosis (TB) is caused by a bacterial infection that affects a number of human organs, primarily the lungs, but also the liver, spleen, and spine, causing key symptoms of fever, fatigue, and persistent cough, and if not treated properly, can be fatal. Every year, 10 million individuals become ill with active TB resulting with a mortality approximating 1.5 million. Current treatment guidelines recommend oral administration of a combination of first-line anti-TB drugs for at least 6 months. While efficacious under optimum conditions, ‘Directly Observed Therapy Short-course’ (DOTS) is not without problems. The long treatment time and poor pharmacokinetics, alongside drug side effects lead to poor patient compliance and has accelerated the emergence of multi-drug resistant (MDR) organisms. All this, combined with the limited number of newly discovered TB drugs to treat MDR-TB and shorten standard therapy time, has highlighted the need for new targeted drug delivery systems. In this respect, there has been recent focus on micro- and nano-particle technologies to prepare organic or/and metal particles loaded with TB drugs to enhance their efficacy by targeted delivery via the inhaled route. In this review, we provide a brief overview of the current epidemiology of TB, and risk factors for progression of latent stage tuberculosis (LTBI) to the active TB. We identify current TB treatment regimens, newly discovered TB drugs, and identify studies that have used micro- or nano-particles technologies to design a reliable inhalation drug delivery system to treat TB more effectively.
AU  - Alzahabi,KH
AU  - Usmani,O
AU  - Georgiou,TK
AU  - Ryan,MP
AU  - Robertson,BD
AU  - Tetley,TD
AU  - Porter,AE
DO  - 10.1042/ETLS20190154
EP  - 600
PY  - 2020///
SN  - 2397-8554
SP  - 581
TI  - Approaches to treating tuberculosis by encapsulating metal ions and anti-mycobacterial drugs utilizing nano- and microparticle technologies
T2  - Emerging Topics in Life Sciences
UR  - http://dx.doi.org/10.1042/ETLS20190154
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000599950400004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://portlandpress.com/emergtoplifesci/article/4/6/581/227297/Approaches-to-treating-tuberculosis-by
UR  - http://hdl.handle.net/10044/1/87049
VL  - 4
ER  -
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