Imperial College London
Alternate

MrBarrySampson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 3644b.sampson Website

 
 
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Location

 

GMO 02 Medical Oncology BlockMedical OncologyCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sampson:2012:10.1258/acb.2011.011141,
author = {Sampson and Hart},
doi = {10.1258/acb.2011.011141},
journal = {Annals of Clinical Biochemistry},
pages = {118--131},
title = {Clinical usefulness of blood metal measurements to assess the failure of metal-on-metal orthopaedic implants.},
url = {http://dx.doi.org/10.1258/acb.2011.011141},
volume = {49},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In April 2010, a Medicines and Healthcare Products Regulatory Agency safety alert concerning all metal-on-metal (MOM) hipreplacements recommended measuring chromium and cobalt concentrations when managing patients with painfulprostheses. The need for this review is illustrated by the recent surge in requests for these blood tests from orthopaedicsurgeons following this alert. The aim is to provide guidance to laboratories in assessing these requests and advisingclinicians on interpretation. First, we summarize the basic terminology regarding the types of hip replacements, with emphasison the MOM type. Second, we describe the clinical concerns over implant-derived wear debris in the local tissues and distantsites. Analytical aspects of the measurement of the relevant metal ions and what factors affect the levels measured arediscussed. The application of inductively coupled plasma mass spectrometry techniques to the measurement of these metalsis considered in detail. The biological effects of metal wear products are summarized with local toxicity and systemicbiological effects considered, including carcinogenicity, genotoxicity and systemic toxicity. Clinical cases are used to illustratepertinent points.
AU  - Sampson
AU  - Hart
DO  - 10.1258/acb.2011.011141
EP  - 131
PY  - 2012///
SN  - 0004-5632
SP  - 118
TI  - Clinical usefulness of blood metal measurements to assess the failure of metal-on-metal orthopaedic implants.
T2  - Annals of Clinical Biochemistry
UR  - http://dx.doi.org/10.1258/acb.2011.011141
UR  - http://hdl.handle.net/10044/1/28408
VL  - 49
ER  -
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