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@article{Scott:2023:10.1038/s41388-023-02604-x,
author = {Scott, E and Hodgson, K and Calle, B and Turner, H and Cheung, K and Bermudez, A and Marques, FJG and Pye, H and Yo, EC and Islam, K and Oo, HZ and McClurg, UL and Wilson, L and Thomas, H and Frame, FM and Orozco-Moreno, M and Bastian, K and Arredondo, HM and Roustan, C and Gray, MA and Kelly, L and Tolson, A and Mellor, E and Hysenaj, G and Goode, EA and Garnham, R and Duxfield, A and Heavey, S and Stopka-Farooqui, U and Haider, A and Freeman, A and Singh, S and Johnston, EW and Punwani, S and Knight, B and McCullagh, P and McGrath, J and Crundwell, M and Harries, L and Bogdan, D and Westaby, D and Fowler, G and Flohr, P and Yuan, W and Sharp, A and de, Bono J and Maitland, NJ and Wisnovsky, S and Bertozzi, CR and Heer, R and Guerrero, RH and Daugaard, M and Leivo, J and Whitaker, H and Pitteri, S and Wang, N and Elliott, DJ and Schumann, B and Munkley, J},
doi = {10.1038/s41388-023-02604-x},
journal = {Oncogene},
pages = {926--937},
title = {Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth},
url = {http://dx.doi.org/10.1038/s41388-023-02604-x},
volume = {42},
year = {2023}
}

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TY  - JOUR
AB  - Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O-glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O-glycosylation as an important driver of prostate cancer progression.
AU  - Scott,E
AU  - Hodgson,K
AU  - Calle,B
AU  - Turner,H
AU  - Cheung,K
AU  - Bermudez,A
AU  - Marques,FJG
AU  - Pye,H
AU  - Yo,EC
AU  - Islam,K
AU  - Oo,HZ
AU  - McClurg,UL
AU  - Wilson,L
AU  - Thomas,H
AU  - Frame,FM
AU  - Orozco-Moreno,M
AU  - Bastian,K
AU  - Arredondo,HM
AU  - Roustan,C
AU  - Gray,MA
AU  - Kelly,L
AU  - Tolson,A
AU  - Mellor,E
AU  - Hysenaj,G
AU  - Goode,EA
AU  - Garnham,R
AU  - Duxfield,A
AU  - Heavey,S
AU  - Stopka-Farooqui,U
AU  - Haider,A
AU  - Freeman,A
AU  - Singh,S
AU  - Johnston,EW
AU  - Punwani,S
AU  - Knight,B
AU  - McCullagh,P
AU  - McGrath,J
AU  - Crundwell,M
AU  - Harries,L
AU  - Bogdan,D
AU  - Westaby,D
AU  - Fowler,G
AU  - Flohr,P
AU  - Yuan,W
AU  - Sharp,A
AU  - de,Bono J
AU  - Maitland,NJ
AU  - Wisnovsky,S
AU  - Bertozzi,CR
AU  - Heer,R
AU  - Guerrero,RH
AU  - Daugaard,M
AU  - Leivo,J
AU  - Whitaker,H
AU  - Pitteri,S
AU  - Wang,N
AU  - Elliott,DJ
AU  - Schumann,B
AU  - Munkley,J
DO  - 10.1038/s41388-023-02604-x
EP  - 937
PY  - 2023///
SN  - 0950-9232
SP  - 926
TI  - Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
T2  - Oncogene
UR  - http://dx.doi.org/10.1038/s41388-023-02604-x
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000925962300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://www.nature.com/articles/s41388-023-02604-x
UR  - http://hdl.handle.net/10044/1/107525
VL  - 42
ER  -

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