Imperial College London
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DrBarrySeemungal

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 7042b.seemungal Website

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10L16Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Hadi:2022:10.1101/2021.12.03.471139,
author = {Hadi, Z and Pondeca, Y and Calzolari, E and Mahmud, M and Chepisheva, M and Smith, RM and Rust, H and Sharp, DJ and Seemungal, BM},
doi = {10.1101/2021.12.03.471139},
publisher = {Cold Spring Harbor Laboratory},
title = {The human brain networks mediating the vestibular sensation of self-motion},
url = {http://dx.doi.org/10.1101/2021.12.03.471139},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Vestibular Agnosia - where peripheral vestibular activation triggers the usual reflex nystagmus response but with attenuated or no self-motion perception - is found in brain disease with disrupted cortical network functioning, e.g. traumatic brain injury (TBI) or neurodegeneration (Parkinson’s Disease). Patients with acute focal hemispheric lesions (e.g. stroke) do not manifest vestibular agnosia. Thus brain network mapping techniques, e.g. resting state functional MRI (rsfMRI), are needed to interrogate functional brain networks mediating vestibular agnosia. Whole-brain rsfMRI was acquired from 39 prospectively recruited acute TBI patients with preserved peripheral vestibular function, along with self-motion perceptual thresholds during passive yaw rotations in the dark. Following quality-control checks, 25 patient scans were analyzed. TBI patients were classified as having vestibular agnosia (n = 11) or not (n = 14) via laboratory testing of self-motion perception. Using independent component analysis, we found altered functional connectivity in the right superior longitudinal fasciculus and left rostral prefrontal cortex in vestibular agnosia. Moreover, regions of interest analyses showed both inter-hemispheric and intra-hemispheric network disruption in vestibular agnosia. In conclusion, our results show that vestibular agnosia is mediated by bilateral anterior and posterior network dysfunction and reveal the distributed brain mechanisms mediating vestibular self-motion perception.
AU  - Hadi,Z
AU  - Pondeca,Y
AU  - Calzolari,E
AU  - Mahmud,M
AU  - Chepisheva,M
AU  - Smith,RM
AU  - Rust,H
AU  - Sharp,DJ
AU  - Seemungal,BM
DO  - 10.1101/2021.12.03.471139
PB  - Cold Spring Harbor Laboratory
PY  - 2022///
TI  - The human brain networks mediating the vestibular sensation of self-motion
UR  - http://dx.doi.org/10.1101/2021.12.03.471139
UR  - https://www.biorxiv.org/content/10.1101/2021.12.03.471139v2
UR  - http://hdl.handle.net/10044/1/99295
ER  -
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