Imperial College London
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DrBarrySeemungal

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 7042b.seemungal Website

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10L16Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yousif:2016:10.1111/ene.12947,
author = {Yousif, N and Bhatt, H and Bain, P and Nandi and Seemungal},
doi = {10.1111/ene.12947},
journal = {European Journal of Neurology},
pages = {668--670},
title = {The effect of Pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception},
url = {http://dx.doi.org/10.1111/ene.12947},
volume = {23},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and purposeDeep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) reduces the number of falls in patients with Parkinson's disease (PD). It was hypothesized that enhanced sensory processing contributes to this PPN-mediated gait improvement.MethodsFour PD patients (and eight matched controls) with implanted bilateral PPN and subthalamic nucleus DBS electrodes were assessed on postural (with/without vision) and vestibular perceptual threshold tasks.ResultsPedunculopontine nucleus ON stimulation (compared to OFF) lowered vestibular perceptual thresholds but there was a disproportionate increase in the normal sway increase on going from light to dark.ConclusionsThe disproportionate increased sway with PPN stimulation in the dark may paradoxically improve balance function since mechanoreceptor signals rapidly adapt to continuous pressure stimulation from postural akinesia. Additionally, the PPN-mediated vestibular signal enhancement also improves the monitoring of postural sway. Overall, PPN stimulation may improve sensory feedback and hence balance performance.
AU  - Yousif,N
AU  - Bhatt,H
AU  - Bain,P
AU  - Nandi
AU  - Seemungal
DO  - 10.1111/ene.12947
EP  - 670
PY  - 2016///
SN  - 1468-1331
SP  - 668
TI  - The effect of Pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception
T2  - European Journal of Neurology
UR  - http://dx.doi.org/10.1111/ene.12947
UR  - http://hdl.handle.net/10044/1/27843
VL  - 23
ER  -
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