Imperial College London
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DrBarrySeemungal

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 7042b.seemungal Website

 
 
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Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
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Location

 

10L16Lab BlockCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kaski:2015:brain/awv370,
author = {Kaski, D and Quadir, S and Nigmatullina, Y and Malhotra, PA and Bronstein, AM and Seemungal, BM},
doi = {brain/awv370},
journal = {Brain},
pages = {392--403},
title = {Temporoparietal encoding of space and time during vestibular-guided orientation},
url = {http://dx.doi.org/10.1093/brain/awv370},
volume = {139},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - When we walk in our environment, we readily determine our travelled distance and location using visual cues. In the dark, estimating travelled distance uses a combination of somatosensory and vestibular (i.e. inertial) cues. The observed inability of patients with complete peripheral vestibular failure to update their angular travelled distance during active or passive turns in the dark implies a privileged role for vestibular cues during human angular orientation. As vestibular signals only provide inertial cues of self-motion (e.g. velocity, °/s), the brain must convert motion information to distance information (a process called ‘path integration’) to maintain our spatial orientation during self-motion in the dark. It is unknown, however, what brain areas are involved in converting vestibular-motion signals to those that enable such vestibular-spatial orientation. Hence, using voxel-based lesion–symptom mapping techniques, we explored the effect of acute right hemisphere lesions in 18 patients on perceived angular position, velocity and motion duration during whole-body angular rotations in the dark. First, compared to healthy controls’ spatial orientation performance, we found that of the 18 acute stroke patients tested, only the four patients with damage to the temporoparietal junction showed impaired spatial orientation performance for leftward (contralesional) compared to rightward (ipsilesional) rotations. Second, only patients with temporoparietal junction damage showed a congruent underestimation in both their travelled distance (perceived as shorter) and motion duration (perceived as briefer) for leftward compared to rightward rotations. All 18 lesion patients tested showed normal self-motion perception. These data suggest that the cerebral cortical regions mediating vestibular-motion (‘am I moving?’) and vestibular-spatial perception (‘where am I?’) are distinct. Furthermore, the congruent contralesiona
AU  - Kaski,D
AU  - Quadir,S
AU  - Nigmatullina,Y
AU  - Malhotra,PA
AU  - Bronstein,AM
AU  - Seemungal,BM
DO  - brain/awv370
EP  - 403
PY  - 2015///
SN  - 0006-8950
SP  - 392
TI  - Temporoparietal encoding of space and time during vestibular-guided orientation
T2  - Brain
UR  - http://dx.doi.org/10.1093/brain/awv370
UR  - http://hdl.handle.net/10044/1/28940
VL  - 139
ER  -
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