Imperial College London
Alternate

Professor Brian G Spratt FRS

Faculty of Medicine, School of Public Health

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 3625b.spratt

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hudson:2013:10.1371/journal.pone.0062117,
author = {Hudson, LO and Murphy, CR and Spratt, BG and Enright, MC and Elkins, K and Nguyen, C and Terpstra, L and Gombosev, A and Kim, D and Hannah, P and Mikhail, L and Alexander, R and Moore, DF and Huang, SS},
doi = {10.1371/journal.pone.0062117},
journal = {PLOS One},
title = {Diversity of Methicillin-Resistant Staphylococcus aureus (MRSA) strains isolated from inpatients of 30 hospitals in Orange County, California},
url = {http://dx.doi.org/10.1371/journal.pone.0062117},
volume = {8},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is a need for a regional assessment of the frequency and diversity of MRSA to determine major circulating clones and the extent to which community and healthcare MRSA reservoirs have mixed. We conducted a prospective cohort study of inpatients in Orange County, California, systematically collecting clinical MRSA isolates from 30 hospitals, to assess MRSA diversity and distribution. All isolates were characterized by spa typing, with selective PFGE and MLST to relate spa types with major MRSA clones. We collected 2,246 MRSA isolates from hospital inpatients. This translated to 91/10,000 inpatients with MRSA and an Orange County population estimate of MRSA inpatient clinical cultures of 86/100,000 people. spa type genetic diversity was heterogeneous between hospitals, and relatively high overall (72%). USA300 (t008/ST8), USA100 (t002/ST5) and a previously reported USA100 variant (t242/ST5) were the dominant clones across all Orange County hospitals, representing 83% of isolates. Fifteen hospitals isolated more t008 (USA300) isolates than t002/242 (USA100) isolates, and 12 hospitals isolated more t242 isolates than t002 isolates. The majority of isolates were imported into hospitals. Community-based infection control strategies may still be helpful in stemming the influx of traditionally community-associated strains, particularly USA300, into the healthcare setting.
AU  - Hudson,LO
AU  - Murphy,CR
AU  - Spratt,BG
AU  - Enright,MC
AU  - Elkins,K
AU  - Nguyen,C
AU  - Terpstra,L
AU  - Gombosev,A
AU  - Kim,D
AU  - Hannah,P
AU  - Mikhail,L
AU  - Alexander,R
AU  - Moore,DF
AU  - Huang,SS
DO  - 10.1371/journal.pone.0062117
PY  - 2013///
SN  - 1932-6203
TI  - Diversity of Methicillin-Resistant Staphylococcus aureus (MRSA) strains isolated from inpatients of 30 hospitals in Orange County, California
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0062117
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318340400075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/30015
VL  - 8
ER  -
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