Imperial College London
Alternate

Professor Brian G Spratt FRS

Faculty of Medicine, School of Public Health

Emeritus Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3625b.spratt

 
 
//

Location

 

G30Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Murphy:2013:10.1086/670631,
author = {Murphy, CR and Hudson, LO and Spratt, BG and Elkins, K and Terpstra, L and Gombosev, A and Nguyen, C and Hannah, P and Alexander, R and Enright, MC and Huang, SS},
doi = {10.1086/670631},
journal = {Infection Control and Hospital Epidemiology},
pages = {581--587},
title = {Predictors of Hospitals with Endemic Community-Associated Methicillin-Resistant Staphylococcus aureus},
url = {http://dx.doi.org/10.1086/670631},
volume = {34},
year = {2013}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE—We sought to identify hospital characteristics associated with communityassociatedmethicillin-resistant Staphylococcus aureus (CA-MRSA) carriage among inpatients.DESIGN—Prospective cohort study.SETTING—Orange County, California.PARTICIPANTS—Thirty hospitals in a single county.METHODS—We collected clinical MRSA isolates from inpatients in 30 of 31 hospitals inOrange County, California, from October 2008 through April 2010. We characterized isolates byspa typing to identify CA-MRSA strains. Using California’s mandatory hospitalization data set,we identified hospital-level predictors of CA-MRSA isolation.RESULTS—CA-MRSA strains represented 1,033 (46%) of 2,246 of MRSA isolates. By hospital,the median percentage of CA-MRSA isolates was 46% (range, 14%–81%). In multivariatemodels, CA-MRSA isolation was associated with smaller hospitals (odds ratio [OR], 0.97, or 3%decreased odds of CA-MRSA isolation per 1,000 annual admissions; P < .001), hospitals withmore Medicaid-insured patients (OR, 1.2; P = .002), and hospitals with more patients with low comorbidity scores (OR, 1.3; P < .001). Results were similar when restricted to isolates frompatients with hospital-onset infection.CONCLUSIONS—Among 30 hospitals, CA-MRSA comprised nearly half of MRSA isolates.There was substantial variability in CA-MRSA penetration across hospitals, with more CA-MRSAin smaller hospitals with healthier but socially disadvantaged patient populations. Additionalresearch is needed to determine whether infection control strategies can be successful in targetingCA-MRSA influx.
AU  - Murphy,CR
AU  - Hudson,LO
AU  - Spratt,BG
AU  - Elkins,K
AU  - Terpstra,L
AU  - Gombosev,A
AU  - Nguyen,C
AU  - Hannah,P
AU  - Alexander,R
AU  - Enright,MC
AU  - Huang,SS
DO  - 10.1086/670631
EP  - 587
PY  - 2013///
SN  - 1559-6834
SP  - 581
TI  - Predictors of Hospitals with Endemic Community-Associated Methicillin-Resistant Staphylococcus aureus
T2  - Infection Control and Hospital Epidemiology
UR  - http://dx.doi.org/10.1086/670631
UR  - http://hdl.handle.net/10044/1/30648
VL  - 34
ER  -
Download