Imperial College London
Alternate

Professor Brian G Spratt FRS

Faculty of Medicine, School of Public Health

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 7594 3625b.spratt

 
 
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Location

 

G30Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Donker:2017:10.1099/mgen.0.000113,
author = {Donker, T and Reuter, S and Scriberras, J and Reynolds, R and Brown, NM and Török, ME and James, R and Network, EOEMR and Aanensen, DM and Bentley, SD and Holden, MTG and Parkhill, J and Spratt, BG and Peacock, SJ and Feil, EJ and Grundmann, H},
doi = {10.1099/mgen.0.000113},
journal = {Microbial Genomics},
title = {Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns.},
url = {http://dx.doi.org/10.1099/mgen.0.000113},
volume = {3},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which resistance spreads between patients in different hospitals is required in order to design effective control strategies. We measured the differences between bacterial populations of 52 hospitals in the United Kingdom and Ireland, using whole-genome sequences from 1085 MRSA clonal complex 22 isolates collected between 1998 and 2012. The genetic differences between bacterial populations were compared with the number of patients transferred between hospitals and their regional structure. The MRSA populations within single hospitals, regions and countries were genetically distinct from the rest of the bacterial population at each of these levels. Hospitals from the same patient referral regions showed more similar MRSA populations, as did hospitals sharing many patients. Furthermore, the bacterial populations from different time-periods within the same hospital were generally more similar to each other than contemporaneous bacterial populations from different hospitals. We conclude that, while a large part of the dispersal and expansion of MRSA takes place among patients seeking care in single hospitals, inter-hospital spread of resistant bacteria is by no means a rare occurrence. Hospitals are exposed to constant introductions of MRSA on a number of levels: (1) most MRSA is received from hospitals that directly transfer large numbers of patients, while (2) fewer introductions happen between regions or (3) across national borders, reflecting lower numbers of transferred patients. A joint coordinated control effort between hospitals, is therefore paramount for the national control of MRSA, antibiotic-resistant bacteria and other hospital-associated pathogens.
AU  - Donker,T
AU  - Reuter,S
AU  - Scriberras,J
AU  - Reynolds,R
AU  - Brown,NM
AU  - Török,ME
AU  - James,R
AU  - Network,EOEMR
AU  - Aanensen,DM
AU  - Bentley,SD
AU  - Holden,MTG
AU  - Parkhill,J
AU  - Spratt,BG
AU  - Peacock,SJ
AU  - Feil,EJ
AU  - Grundmann,H
DO  - 10.1099/mgen.0.000113
PY  - 2017///
SN  - 2057-5858
TI  - Population genetic structuring of methicillin-resistant Staphylococcus aureus clone EMRSA-15 within UK reflects patient referral patterns.
T2  - Microbial Genomics
UR  - http://dx.doi.org/10.1099/mgen.0.000113
UR  - http://hdl.handle.net/10044/1/51871
VL  - 3
ER  -
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