Summary
Dr. Balvinder Handa completed his training in General Cardiology, Cardiac Electrophysiology and Complex Devices at Imperial College London Healthcare NHS Trust. He has subsequently moved to Australia to practice at Sir Charles Gairdner Hospital in Perth. He is an expert in management of all heart rhythm disorders and his area of expertise include general cardiology, catheter ablation (atrial fibrillation, atrial flutter, AT, SVTs, ventricular ectopy and ventricular tachycardia), implantation of pacemakers and complex devices (ICD, CRT-P, CRT-D, conduction system pacing and subcutaneous ICDs).
He undertook his PhD titled "The Effects of Gap Junction Coupling and Fibrosis on the Mechanism and Electrophenotype of Myocardial Fibrillation" under the supervision of Dr. Fu Siong Ng and Prof. Nicholas Peters. His research focused on the underlying mechanisms sustaining ventricular fibrillation and atrial fibrillation, and the role of fibrosis and gap junction coupling in arrhythmogenesis. During the course of his PhD he developed patented novel fibrillation mapping techniques using Granger causality analysis with Dr. Xinyang Li.
His research work has been presented at multiple national and international Cardiology and Cardiac Electrophysiology conferences (ESC, HRS, EHRA, HRC, BCS) and has been featured in the conference highlights sessions at both EHRA and ESC.
He has received numerous international travel grants and been nominated on three separate occasions for the Young Investigator Award on a national and international stage for his research work:
1) Young Investigator Award Winner, Heart Rhythm Congress 2019, Birmingham UK.
2) Young Investigator Award Finalist at the European Heart Rhythm Association Congress, Lisbon, Portugal 2019
3) Young Investigator Award Finalist at the Sudden Arrhythmic Death Syndrome Foundation event at the Heart Rhythm Society (HRS) Congress, San Francisco, USA 2019.
Dr. Handa graduated from Medicine at Imperial College London in 2011 with multiple distinctions. He was awarded a First Class (Honours) BSc degree in Cardiovascular Sciences. He completed his PhD at the National Heart and Lung Institute at Imperial College London. Dr. Handa achieved the MRCP accreditation prior to starting his specialist training in Cardiology in a highly competitive training post in the London Deanery (North West Thames).
He has a strong interest in medical education, and is a lecturer on the Cardiovascular Sciences BSc course and has supervised student research projects on the course. He has published a number of chapters in academic textbooks.
Publications
Chowdhury RA, Debney MT, Protti A, Handa BS, Patel KHK, Lyon AR, Shah AM, Ng FS, Peters NS. Rotigaptide Infusion for the First 7 Days After Myocardial Infarction-Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border-Zone and Arrhythmia Inducibility. J Am Heart Assoc. 2021 May 4;10(9):e020006. doi: 10.1161/JAHA.120.020006. Epub 2021 Apr 17. PMID: 33870715; PMCID: PMC8200720.
Jabbour RJ, Owen TJ, Pandey P, Reinsch M, Wang B, King O, Couch LS, Pantou D, Pitcher DS, Chowdhury RA, Pitoulis FG, Handa BS, Kit-Anan W, Perbellini F, Myles RC, Stuckey DJ, Dunne M, Shanmuganathan M, Peters NS, Ng FS, Weinberger F, Terracciano CM, Smith GL, Eschenhagen T, Harding SE. In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight. 2021 Aug 9;6(15):e144068. doi: 10.1172/jci.insight.144068. PMID: 34369384; PMCID: PMC8410032.
Handa BS, Li X, Aras KK, Qureshi NA, Mann I, Chowdhury RA, Whinnett ZI, Linton NWF, Lim PB, Kanagaratnam P, Efimov IR, Peters NS, Ng FS. Response by Handa et al to Letter Regarding Article, "Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers". Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008951. doi: 10.1161/CIRCEP.120.008951. Epub 2020 Aug 18. PMID: 32809880; PMCID: PMC7439311.
Li X, Shi X, Handa BS, Sau A, Zhang B, Qureshi NA, Whinnett ZI, Linton NWF, Lim PB, Kanagaratnam P, Peters NS, Ng FS. Classification of Fibrillation Organisation Using Electrocardiograms to Guide Mechanism-Directed Treatments. Front Physiol. 2021 Nov 11;12:712454. doi: 10.3389/fphys.2021.712454. PMID: 34858198; PMCID: PMC8632359.
Ng FS, Handa BS, Li X, Peters NS. Toward Mechanism-Directed Electrophenotype-Based Treatments for Atrial Fibrillation. Front Physiol. 2020 Aug 28;11:987.
Handa BS, Li X, Baxan N, Roney CH, Shchendrygina A, Mansfield CA, Jabbour R, Pitcher D, Chowdhury RA, Peters NS, Ng FS. Ventricular fibrillation mechanism and global fibrillatory organisation are determined by gap junction coupling and fibrosis pattern, Cardiovascular Research, , cvaa141, https://doi.org/10.1093/cvr/cvaa141
Handa BS, Li X, Aras KK, Qureshi NA, Mann I, Chowdhury RA, Whinnett ZI, Linton NWF, Lim PB, Kanagaratnam P, Efimov IR, Peters NS, Ng FS. Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers. Circ Arrhythm Electrophysiol. 2020 Mar;13(3):e008237.
Li, X., Roney, C.H., Handa, B.S. et al. Standardised Framework for Quantitative Analysis of Fibrillation Dynamics. Sci Rep 9, 16671 (2019) doi:10.1038/s41598-019-52976-y
Handa BS, Lawal S, Wright IJ, Li X, Cabello-García J, Mansfield C, et al. Interventricular Differences in Action Potential Duration Restitution Contribute to Dissimilar Ventricular Rhythms in ex vivo Perfused Hearts [Internet]. Vol. 6, Frontiers in Cardiovascular Medicine. 2019. p. 34. Available from: https://www.frontiersin.org/article/10.3389/fcvm.2019.00034
Handa BS, Roney CH, Houston C et al. Analytical approaches for myocardial fibrillation signals. Comput Biol Med. 2018;102:315–26.
Meijles DN, Zoumpoulidou G, Markou T, Rostron KA, Patel R, Lay K, Handa BS et al. The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. J Mol Cell Cardiol. 2019 Feb;
Pikkarainen S, Kennedy RA, Marshall AK, Tham el L, Lay K, Kriz TA, Handa BS, Clerk A, Sugden PH. Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes. J Biol Chem. 2009 Oct 2;284(40):27195-210.
Publications
Journals
Kim MY, Nesbitt J, Koutsoftidis S, et al.Kim MY, Nesbitt J, Koutsoftidis S, Brook J, Pitcher D, Cantwell C, Handa B, Jenkins C, Houston C, Rothery S, Jothidasan A, Perkins J, Bristow P, Linton N, Drakakis E, Peters N, Chowdhury R, Kanagaratnam P, Ng FS close, 2023, Immunohistochemical characteristics of local sites that trigger atrial arrhythmias in response to high frequency stimulation, Ep Europace, Vol:25, ISSN:1099-5129, Pages:726-738
Sau A, Ibrahim S, Ahmed A, et al.Sau A, Ibrahim S, Ahmed A, Handa B, Kramer DB, Waks JW, Arnold AD, Howard JP, Qureshi N, Koa-Wing M, Keene D, Malcolme-Lawes L, Lefroy DC, Linton NWF, Lim PB, Varnava A, Whinnett ZI, Kanagaratnam P, Mandic D, Peters NS, Ng FS close, 2022, Artificial intelligence-enabled electrocardiogram to distinguish cavotricuspid isthmus dependence from other atrial tachycardia mechanisms, European Heart Journal – Digital Health, Vol:3, ISSN:2634-3916, Pages:405-414
Li X, Shi X, Handa BS, et al.Li X, Shi X, Handa BS, Sau A, Zhang B, Qureshi NA, Whinnett ZI, Linton N, Lim PB, Kanagaratnam P, Peters N, Ng FS close, 2021, Classification of fibrillation organisation using electrocardiograms to guide mechanism-directed treatments, Frontiers in Physiology, Vol:12, ISSN:1664-042X, Pages:1-14
Jabbour R, Owen T, Pandey P, et al.Jabbour R, Owen T, Pandey P, reinsch M, Wang B, King O, Couch L, Pantou D, Pitcher D, Chowdhury R, Pitoulis F, Handa B, Kit-Anan W, Perbellini F, myles R, Stuckey D, dunne M, Shanmuganathan M, Peters N, Ng FS, weinberger F, Terracciano C, smith G, Eschenhagen T, Harding S close, 2021, In vivo grafting of large engineered heart tissue patches for cardiac repair, Jci Insight, Vol:6, ISSN:2379-3708, Pages:1-13
Chowdhury R, Debney M, Protti A, et al.Chowdhury R, Debney M, Protti A, Handa B, Patel K, Lyon A, shah A, ng FS, Peters N close, 2021, Rotigaptide Infusion for the First 7 Days After Myocardial Infarction–Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border-Zone and Arrhythmia Inducibility, Journal of the American Heart Association, Vol:10, ISSN:2047-9980, Pages:1-18
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