DrBalvinderHanda

Summary

Dr. Balvinder Handa is a Clinical Research Fellow in Cardiac Electrophysiology at the National Heart and Lung Institute, and a Cardiology Registrar at Imperial College London Healthcare NHS Trust. His current research interest and the topic of his PhD is mechanisms of complex arrhythmogenesis in myocardial fibrillation and development of new fibrillation analysis tools. His primary interest is in the role of fibrosis and gap junction modulation in fibrillation. He is undertaking his PhD under the primary supervision of Dr. Fu Siong Ng and co-supervision of Prof. Nicholas Peters.

His work on the role of differing patterns of fibrosis on fibrillation mechanisms has shown a spectrum of fibrillation mechanisms and developed the concept of 'electro-phenotype' underlying fibrillation.

He has been nominated on three seperate occassions for the Young Investigator Award on a national and international stage for his research work:

1) Young Investigator Award Winner, Heart Rhythm Congress 2019, Birmingham UK. 

2) Young Investigator Award Finalist at the European Heart Rhythm Association Congress, Lisbon, Portugal 2019 

3) Young Investigator Award Finalist at the Sudden Arrhythmic Death Syndrome Foundation event at the Heart Rhythm Society (HRS) Congress, San Francisco, USA 2019.

Concurrently, by working in close collaboration with Dr. Xinyang Li, he has developed a novel low resolution fibrillation mapping tool which has been filed for a patent. 

Dr. Handa studied Medicine at Imperial College London between 2005 and 2011. He was awarded a First Class (Honours) BSc degree in Cardiovascular Sciences and awarded Distinctions in Clinical Medicine, Pharmacology and Therapeutics, Psychiatry and Obstetrics and Gynaecology for his final MBBS degree.

Dr. Handa achieved the MRCP prior to starting his specialist training in Cardiology in a highly competitive training post in the London Deanery (North West Thames). 

He has a strong interest in medical education, and is a lecturer on the Cardiovascular Sciences BSc course and has supervised student research projects on the course. He has tutored junior doctor undertaking the PACES examination for MRCP accreditation and is an examiner on the CentralPaces course.  

Publications

Li, X., Roney, C.H., Handa, B.S. et al. Standardised Framework for Quantitative Analysis of Fibrillation Dynamics. Sci Rep 9, 16671 (2019) doi:10.1038/s41598-019-52976-y

Handa BS, Lawal S, Wright IJ, Li X, Cabello-García J, Mansfield C, et al. Interventricular Differences in Action Potential Duration Restitution Contribute to Dissimilar Ventricular Rhythms in ex vivo Perfused Hearts    [Internet]. Vol. 6, Frontiers in Cardiovascular Medicine. 2019. p. 34. Available from: https://www.frontiersin.org/article/10.3389/fcvm.2019.00034 

Handa BS, Roney CH, Houston C et al. Analytical approaches for myocardial fibrillation signals. Comput Biol Med. 2018;102:315–26.

Meijles DN, Zoumpoulidou G, Markou T, Rostron KA, Patel R, Lay K, Handa BS et al. The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. J Mol Cell Cardiol. 2019 Feb;

Pikkarainen S, Kennedy RA, Marshall AK, Tham el L, Lay K, Kriz TA, Handa BS, Clerk A, Sugden PH. Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H(2)O(2)-induced oxidative stress in neonatal rat cardiac myocytes. J Biol Chem. 2009 Oct 2;284(40):27195-210.

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