Summary
Ben Jones is a Senior Clinical Research Fellow within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focussed on the translational pharmacology of G protein coupled receptors in metabolic disease.
He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor.
After completing clinical training in 2020 he has recently been awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF). Current work aims to establish the mechanism of action of biased incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity.
Publications
Journals
Manchanda Y, Bitsi S, Chen S, et al., 2023, Enhanced endosomal signaling and desensitization of GLP-1R versus GIPR in pancreatic beta cells, Endocrinology, Vol:164, ISSN:0013-7227, Pages:1-15
Thayabaran D, Tsui APT, Ebmeier S, et al., 2023, The effect of adjusting LDL-cholesterol for Lp(a)-cholesterol on the diagnosis of Familial Hypercholesterolaemia., J Clin Lipidol, ISSN:1933-2874
Padam P, Barton L, Wilson S, et al., 2022, Lipid-lowering with inclisiran: areal-world single-centre experience, Open Heart, Vol:9, ISSN:2053-3624
Hope D, Hinds C, Lopes T, et al., 2022, Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss, Cell Reports Medicine, Vol:3, ISSN:2666-3791
McGlone ER, Dunsterville C, Carling D, et al., 2022, Hepatocyte cholesterol content modulates glucagon receptor signalling, Molecular Metabolism, Vol:63, ISSN:2212-8778