Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focussed on the translational pharmacology of G protein coupled receptors in metabolic disease.
He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor.
After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship.
Current work aims to establish the mechanism of action of biased incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity.
et al., 2024, Movement characteristics of international and elite domestic netball players during match-play, International Journal of Performance Analysis in Sport
et al., 2024, Abolishing β-arrestin recruitment is necessary for the full metabolic benefits of G protein-biased glucagon-like peptide-1 receptor agonists, Diabetes, Obesity and Metabolism: a Journal of Pharmacology and Therapeutics, Vol:26, ISSN:1462-8902, Pages:65-77
et al., 2023, GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification, Nature Genetics, Vol:55, ISSN:1061-4036, Pages:1448-1461
et al., 2023, Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism, Diabetes, Obesity and Metabolism, Vol:25, ISSN:1462-8902, Pages:2105-2119
et al., 2023, Hypothalamic and brainstem glucose- dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding, Jci Insight, Vol:8