DrBenJones

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Clinical Research Fellow

Contact

Location

Hammersmith HospitalHammersmith Campus

Summary

Ben Jones is a Senior Clinical Research Fellow within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focussed on the translational pharmacology of G protein coupled receptors in metabolic disease.

He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor.

After completing clinical training in 2020 he has recently been awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF). Current work aims to establish the mechanism of action of biased incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity.

Publications

Journals

Cegla J, Jones B, Ray K, et al.Cegla J, Jones B, Ray K, Padam P, Walji S, David A, Barton L, Wilson S, De Lorenzo F close, 2022, Lipid-lowering with inclisiran: A real-world single centre experience, Open Heart, ISSN:2053-3624

Hope D, Hinds C, Lopes T, et al.Hope D, Hinds C, Lopes T, Vincent M, Shrewsbury J, Yu A, Davies I, Scott R, Jones B, Murphy K, Minnion J, Sardini A, Carling D, Lutz T, Bloom S, Tan T, Owen B close, 2022, Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss, Cell Reports Medicine, Vol:3, ISSN:2666-3791

McGlone ER, Dunsterville C, Carling D, et al.McGlone ER, Dunsterville C, Carling D, tomas A, Bloom S, Tan T, Jones B close, 2022, Hepatocyte cholesterol content modulates glucagon receptor signalling, Molecular Metabolism, Vol:63, ISSN:2212-8778

Jones B, Burade V, Akalestou E, et al.Jones B, Burade V, Akalestou E, Manchanda Y, Ramchunder Z, Carrat G, Nguyen-Tu M-S, Marchetti P, Piemonti L, Leclerc I, Thennati R, Vilsboll T, Thorens B, Tomas A, Rutter GA close, 2022, In vivo and in vitro characterization of GL0034, a novel long-acting glucagon-like peptide-1 receptor agonist, Diabetes Obesity & Metabolism, Vol:24, ISSN:1462-8902, Pages:2090-2101

Rossmann K, Akkaya KC, Poc P, et al.Rossmann K, Akkaya KC, Poc P, Charbonnier C, Eichhorst J, Gonschior H, Valavalkar A, Wendler N, Cordes T, Dietzek-Ivansic B, Jones B, Lehmann M, Broichhagen J close, 2022, N-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy, Chemical Science, Vol:13, ISSN:2041-6520, Pages:8605-8617

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