Imperial College London
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DrBenJones

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Metabolic Medicine
 
 
 
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Contact

 

ben.jones

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tomas:2020:10.1016/j.jmb.2019.08.009,
author = {Tomas, A and Jones, B and Leech, C},
doi = {10.1016/j.jmb.2019.08.009},
journal = {Journal of Molecular Biology},
pages = {1347--1366},
title = {New insights into beta cell GLP-1 receptor and cAMP signaling},
url = {http://dx.doi.org/10.1016/j.jmb.2019.08.009},
volume = {432},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells has led to the development of established GLP-1R-based therapies for the long-term preservation of beta cell function. In this review, we discuss recent advances in the current research on the GLP-1/GLP-1R system in beta cells, including the regulation of signaling by endocytic trafficking as well as the application of concepts such as signal bias, allosteric modulation, dual agonism, polymorphic receptor variants, spatial compartmentalization of cAMP signaling and new downstream signaling targets involved in the control of beta cell function.
AU  - Tomas,A
AU  - Jones,B
AU  - Leech,C
DO  - 10.1016/j.jmb.2019.08.009
EP  - 1366
PY  - 2020///
SN  - 0022-2836
SP  - 1347
TI  - New insights into beta cell GLP-1 receptor and cAMP signaling
T2  - Journal of Molecular Biology
UR  - http://dx.doi.org/10.1016/j.jmb.2019.08.009
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31446075
UR  - https://www.sciencedirect.com/science/article/pii/S0022283619305182?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73057
VL  - 432
ER  -
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