Imperial College London
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DrBenJones

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Metabolic Medicine
 
 
 
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Contact

 

ben.jones

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Manchanda:2021:10.1016/j.coemr.2020.07.003,
author = {Manchanda, Y and Bitsi, S and Kang, Y and Jones, B and Tomas, A},
doi = {10.1016/j.coemr.2020.07.003},
journal = {Current Opinion in Endocrine and Metabolic Research},
pages = {19--27},
title = {Spatiotemporal control of GLP-1 receptor activity},
url = {http://dx.doi.org/10.1016/j.coemr.2020.07.003},
volume = {16},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pleiotropic signalling by G protein–coupled receptors is subject to spatiotemporal regulation, which allows precise control over a diverse range of cellular outputs. The glucagon-like peptide-1 receptor (GLP-1R), a class B G protein–coupled receptor important in the control of blood glucose and energy homeostasis, is subject to redistribution within nanoregions of the plasma membrane and throughout the endocytic network, enabling complex patterns of signalling at different locations. Nanodomain segregation of GLP-1Rs promotes the formation of functionally important homo-oligomers and hetero-oligomers and increases proximity to cytosolic effectors. Persistent signalling from GLP-1Rs within the endosomal compartment has also been described. These processes can be dramatically altered by biased and/or modified orthosteric GLP-1R agonists and allosteric modulators. GLP-1R signalling is not a monotonic process and fine-tuning of cellular responses in space and time may provide a means to improve the therapeutic efficacy of GLP-1R agonists.
AU  - Manchanda,Y
AU  - Bitsi,S
AU  - Kang,Y
AU  - Jones,B
AU  - Tomas,A
DO  - 10.1016/j.coemr.2020.07.003
EP  - 27
PY  - 2021///
SN  - 2451-9650
SP  - 19
TI  - Spatiotemporal control of GLP-1 receptor activity
T2  - Current Opinion in Endocrine and Metabolic Research
UR  - http://dx.doi.org/10.1016/j.coemr.2020.07.003
UR  - https://www.sciencedirect.com/science/article/pii/S2451965020300703?via%3Dihub
VL  - 16
ER  -
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