Imperial College London
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DrBenJones

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Metabolic Medicine
 
 
 
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Contact

 

ben.jones

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hinds:2021:10.1038/s41598-021-01912-0,
author = {Hinds, CE and Owen, BM and Hope, DCD and Pickford, P and Jones, B and Tan, TM and Minnion, JS and Bloom, SR},
doi = {10.1038/s41598-021-01912-0},
journal = {Scientific Reports},
pages = {1--17},
title = {A glucagon analogue decreases body weight in mice via signalling in the liver.},
url = {http://dx.doi.org/10.1038/s41598-021-01912-0},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent. As such, a better understanding of chronic glucagon receptor (GCGR) agonism is essential to identify and mitigate potential clinical side-effects. Herein we present a novel, long-acting glucagon analogue (GCG104) with high receptor-specificity and potent in vivo action. It has allowed us to make two important observations about the biology of sustained GCGR agonism. First, it causes weight loss in mice by direct receptor signalling at the level of the liver. Second, subtle changes in GCG104-sensitivity, possibly due to interindividual variation, may be sufficient to alter its effects on metabolic parameters. Together, these findings confirm the liver as a principal target for glucagon-mediated weight loss and provide new insights into the biology of glucagon analogues.
AU  - Hinds,CE
AU  - Owen,BM
AU  - Hope,DCD
AU  - Pickford,P
AU  - Jones,B
AU  - Tan,TM
AU  - Minnion,JS
AU  - Bloom,SR
DO  - 10.1038/s41598-021-01912-0
EP  - 17
PY  - 2021///
SN  - 2045-2322
SP  - 1
TI  - A glucagon analogue decreases body weight in mice via signalling in the liver.
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-021-01912-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34799628
UR  - https://www.nature.com/articles/s41598-021-01912-0
UR  - http://hdl.handle.net/10044/1/93135
VL  - 11
ER  -
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