Publications
168 results found
Glasbey J, Ademuyiwa A, Adisa A, et al., 2021, Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study, The Lancet Oncology, Vol: 22, Pages: 1507-1517, ISSN: 1470-2045
BackgroundSurgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.MethodsThis international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20–60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926.FindingsOf eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notif
Soukup T, Sevdalis N, Green JSA, et al., 2021, Making Tumor Boards More Patient-Centered: Let's Start With the Name, JCO ONCOLOGY PRACTICE, Vol: 17, Pages: 591-+, ISSN: 2688-1527
- Author Web Link
- Cite
- Citations: 6
Winters DA, Soukup T, Sevdalis N, et al., 2021, The cancer multidisciplinary team meeting: in need of change? History, challenges and future perspectives, BJU INTERNATIONAL, Vol: 128, Pages: 271-279, ISSN: 1464-4096
- Author Web Link
- Cite
- Citations: 22
Nathan A, Rashid A, Shukla S, et al., 2021, Immediate Post-Operative PDE5i Therapy Improves Early Erectile Function Outcomes after Robot-Assisted Radical Prostatectomy (RARP), BRITISH JOURNAL OF SURGERY, Vol: 108, Pages: 278-278, ISSN: 0007-1323
Fricker M, Nathan A, Hanna N, et al., 2021, VIRTUAL: Virtual Interactive Surgical Skills Classroom - An Ongoing Randomized Controlled Trial, Publisher: OXFORD UNIV PRESS, ISSN: 0007-1323
Caglic I, Sushentsev N, Shah N, et al., 2021, Comparison of biparametric versus multiparametric prostate MRI for the detection of extracapsular extension and seminal vesicle invasion in biopsy naive patients, EUROPEAN JOURNAL OF RADIOLOGY, Vol: 141, ISSN: 0720-048X
- Author Web Link
- Cite
- Citations: 12
Nathan A, Fricker M, Patel S, et al., 2021, Virtual Interactive Surgical Skills Classroom: Protocol for a Parallel-Group, Noninferiority, Adjudicator-Blinded, Randomized Controlled Trial (VIRTUAL), JMIR RESEARCH PROTOCOLS, Vol: 10, ISSN: 1929-0748
- Author Web Link
- Cite
- Citations: 2
Gao C, Nathan A, Light A, et al., 2021, The impact of COVID-19 on the medium-term outcomes of urological cancer - International prospective 3 year follow up study, Publisher: ELSEVIER, Pages: S1219-S1220, ISSN: 0302-2838
Soukup T, Murtagh GM, Lamb BW, et al., 2021, Gaps and overlaps in cancer multidisciplinary team communication: analysis of speech, Small Group Research, Vol: 52, Pages: 189-219, ISSN: 1046-4964
Guided by the principles of conversation analysis, we examined the communication practices used to negotiate levels of participation in cancer multidisciplinary team meetings and their implications for patient safety. Three cancer teams participated. Thirty-six weekly meetings were video recorded, encompassing 822 case reviews. A cross-section was transcribed using Jefferson notation. We found a low frequency of gaps between speakers (3%), high frequency of overlaps (24%), and no-gaps-no-overlaps (73%), suggesting fast turn transitions. Securing a turn to speak is challenging due to a systematic reduction in turn-taking opportunities. We contribute to group research with the development of a microlevel methodology for studying multidisciplinary teams.
Tan WS, Arianayagam R, Khetrapal P, et al., 2021, Major Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes, EUROPEAN UROLOGY OPEN SCIENCE, Vol: 25, Pages: 39-43, ISSN: 2666-1691
- Author Web Link
- Cite
- Citations: 5
Soukup T, Sevdalis N, Green JSA, et al., 2021, Quality improvement for cancer multidisciplinary teams: lessons learned from the Anglian Germ Cell Cancer Collaborative Group, BRITISH JOURNAL OF CANCER, Vol: 124, Pages: 313-314, ISSN: 0007-0920
- Author Web Link
- Cite
- Citations: 3
Soukup T, Murtagh G, Lamb BW, et al., 2021, Degrees of multidisciplinarity underpinning care planning for patients with cancer in weekly multidisciplinary team meetings: conversation analysis, Journal of Multidisciplinary Healthcare, Vol: 14, Pages: 411-424, ISSN: 1178-2390
Purpose: Despite an increase in research on multidisciplinary team (MDT) meetings, the implementation of MDT-driven decision-making, ie, its fidelity, remains unstudied. We report fidelity using an observational protocol measuring degree to which MDTs in their weekly meetings in the UK adhere to 1) the stages of group decision-making as per the ‘Orientation-Discussion-Decision-Implementation’ framework, and 2) cancer guidelines on the composition and characteristics of their weekly meetings produced by the UK’s Department of Health, UK’s National Cancer Action Team, Cancer Research UK, World Health Organization, and The Expert Advisory Group on Cancer to the Chief Medical Officers of England and Wales.Patients and Methods: This is a prospective cross-sectional observational study of MDT meetings in the UK. Breast, colorectal, and gynecological cancer MDTs across three hospitals in the UK were video recorded over 12 weekly meetings, respectively, encompassing 822 case-reviews. A cross-section of 24 case-reviews was analysed with the main outcomes being adherence to the ‘Orientation-Discussion-Decision-Implementation’ framework, and the cancer guidelines.Results: Eight percent of case-reviews in the MDT meetings involved all five core disciplines including surgeons, oncologists, radiologists, histopathologists, and specialist cancer nurses, and 38% included four. The majority of case-reviews (54%) were between two (25%) or three (29%) disciplines only. Surgeons (83%) and oncologists (8%) most consistently engaged in all stages of decision-making. While all patients put forward for MDT meeting were actually reviewed, 4% of them either bypassed the orientation (case presentation), and 8% did not articulate the final decision to the entire team.Conclusion: We found that, despite being a set policy, cancer case-reviews in MDT meetings are not entirely MDT-driven, with more than half of the case-reviews not adhering to the cancer guideli
Glasbey JC, Omar O, Nepogodiev D, et al., 2021, Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic, BRITISH JOURNAL OF SURGERY, Vol: 108, Pages: 88-96, ISSN: 0007-1323
- Author Web Link
- Cite
- Citations: 43
Soukup T, Lamb BW, Shah NJ, et al., 2020, Relationships Between Communication, Time Pressure, Workload, Task Complexity, Logistical Issues and Group Composition in Transdisciplinary Teams: A Prospective Observational Study Across 822 Cancer Cases, FRONTIERS IN COMMUNICATION, Vol: 5
- Author Web Link
- Cite
- Citations: 4
Glasbey JC, Bhangu A, 2020, Elective cancer surgery in COVID-19–free surgical pathways during the SARS-CoV-2 pandemic: an international, multicenter, comparative cohort study, Journal of Clinical Oncology, Vol: 39, Pages: 66-78, ISSN: 0732-183X
PURPOSEAs cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway.PATIENTS AND METHODSThis international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation).RESULTSOf 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76).CONCLUSIONWithin available resources, dedicated COVID-19–free
Lamb BW, Miah S, Stewart GD, et al., 2020, Development and validation of a short version of the Metric for the Observation of Decision-making in multidisciplinary tumor boards: MODe-Lite
<p>Background: Evidence-based tools are necessary for scientifically improving the way cancer multidisciplinary tumor boards (MTBs) work. Such tools are available but can be difficult to use. We sought to develop a robust observational assessment tool for use by healthcare professionals to improve how MTBs work in everyday practice.Participants and methods: We conducted a retrospective cross-sectional observational study in the United Kingdom between September 2015 and July 2016. Three tumor boards from three teaching hospitals were recruited with 44 members overall. Six weekly meetings (146 consecutive cases) were video recorded and scored using the validated MODe tool. Data were subjected to reliability and validity analysis in the current study for the purposes of developing a shorter version of MODe.Results: In phase 1, a reduction in the original items of MODe was achieved through two focus group meetings with expert assessors based on previous research. Twelve original items were reduced to six domains and have received full agreement by the assessors. In Phase 2, the six domains were subjected to item reliability, convergent validation, and internal consistency testing against MODe-Lite global score, MODe global score, and the individual items of MODe. Significant positive correlations were evidenced across the six domains (p&lt;0.01), providing indication of good reliability and validity. In phase 3, feasibility and high inter-assessor reliability in the use of the tool by two clinical assessors was achieved. A final set of 6 domains, measuring clinical input, holistic input, clinical collaboration, pathology, radiology and management plan were integrated into MODe-Lite.Conclusions: MODe-Lite is an evidence-based tool that can be used by healthcare professionals in everyday practice. It can give cancer MTBs insight into the way they work to facilitate improvements in practice.</p>
Soukup T, Lamb BW, Morbi A, et al., 2020, A multicentre cross-sectional observational study of cancer multidisciplinary teams: Analysis of team decision making, Cancer Medicine, Vol: 9, Pages: 7083-7099, ISSN: 2045-7634
BackgroundMultidisciplinary teams (MDT) formulate expert informed treatment recommendations for people with cancer. We set out to examine how the factors proposed by the functional perspective of group decision making (DM), that is, interaction process, internal factors (factors emanating from within the group such as group size), external circumstances (factors coming from the outside of the team), and case‐complexity affect the quality of MDT decision making.MethodsThis was a cross‐sectional observational study. Three cancer MDTs were recruited with 44 members overall and 30 of their weekly meetings filmed. Validated observational instruments were used to measure quality of DM, interactions, and complexity of 822 case discussions.ResultsThe full regression model with the variables proposed by the functional perspective was significant, R2 = 0.52, F(20, 801) = 43.47, P < .001, adjusted R2 = 0.51. Positive predictors of DM quality were asking questions (P = .001), providing answers (P = .001), team size (P = .007), gender balance (P = .003), and clinical complexity (P = .001), while negative socioemotional reactions (P = .007), gender imbalance (P = .003), logistical issues (P = .001), time‐workload pressures (P = .002), and time spent in the meeting (P = .001) were negative predictors. Second half of the meetings also saw significant decrease in the DM quality (P = .001), interactions (P = .001), group size (P = .003), and clinical complexity (P = .001), and an increase in negative socioemotional reactions (P = .001) and time‐workload pressures (P = .001).DiscussionTo the best of our knowledge, this is the first study to attempt to assess the factors proposed by the functional perspective in cancer MDTs. One novel finding is the effect of sociocognitive factors on team DM quality, while another is the cognitive‐catch 22 effect: while the case discussions are significantly simpler in the second half of the meeting, there is significantly less time left to discuss
Soukup T, Morbi A, Lamb BW, et al., 2020, A measure of case complexity for streamlining workflow in multidisciplinary tumor boards: Mixed methods development and early validation of the MeDiC tool, Cancer Medicine, Vol: 9, Pages: 5143-5154, ISSN: 2045-7634
Background and ObjectiveThere is increasing emphasis in cancer care globally for care to be reviewed and managed by multidisciplinary teams (ie, in tumor boards). Evidence and recommendations suggest that the complexity of each patient case needs to be considered as care is planned; however, no tool currently exists for cancer teams to do so. We report the development and early validation of such a tool.MethodsWe used a mixed‐methods approach involving psychometric evaluation and expert review to develop the Measure of case‐Discussion Complexity (MeDiC) between May 2014 and November 2016. The study ran in six phases and included ethnographic interviews, observations, surveys, feasibility and reliability testing, expert consensus, and multiple expert‐team reviews.ResultsPhase‐1 : case complexity factors identified through literature review and expert interviews; Phase‐2 : 51 factors subjected to iterative review and content validation by nine cancer teams across four England Trusts with nine further items identified; Phase 3 : 60 items subjected to expert review distilled to the most relevant; Phase 4 : item weighing and further content validation through a national UK survey; Phases 5 and 6 : excellent interassessor reliability between clinical and nonclinical observers, and adequate validity on 903 video case discussions achieved. A final set of 27 factors, measuring clinical and logistical complexities were integrated into MeDiC.ConclusionsMeDiC is an evidence‐based and expert‐driven tool that gauges the complexity of cancer cases. MeDiC may be used as a clinical quality assurance and screening tool for tumor board consideration through case selection and prioritization.
Soukup T, Lamb BW, Sevdalis N, et al., 2020, Streamlining cancer multidisciplinary team meetings: challenges and solutions, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 81, ISSN: 1750-8460
- Author Web Link
- Cite
- Citations: 19
Habib A, Connor M, Boxall N, et al., 2020, Improving quality of life for Muslim patients requiring a stoma: A critical review of theological and psychosocial issues, Surgical Practice, Vol: 24, Pages: 29-36, ISSN: 1744-1625
ObjectiveThe impact of a stoma on the health‐related quality of life (HRQoL) in patients is irrespective of faith. Muslim patients report lower quality of life and spiritual wellbeing following stoma surgery as compared to others. This critical review aims to improve awareness of Islamic practices and HRQoL outcomes in this cohort of patients amongst healthcare professionals.Methodology.An extensive non‐systematic search of EMBASE, MEDLINE and Google Scholar was performed for original research articles pertaining to health related quality of life (HRQoL), stoma care and impact on religious practice in Muslim patients. A narrative synthesis of extracted data was performed and presented using basic thematic analysis.ResultsThe findings from the 10 original articles, including 954 participants, were identified. Perceptions of cleanliness emerged as a concern to Muslim patients with stomas as it is core to the performance of prayer. Muslim patients with stomas are known to avoid or reduce participation in prayers due to perceived inferior hygiene and fear of leakage. The consensus opinion from Islamic scholars is that they can pray normally, attend mosque and perform the Hajj pilgrimage. Stoma patients may fast in the Holy month of Ramadan provided it is medically safe. Evidence suggests religion‐specific counselling can reduce the detrimental effect on HRQoL of Muslim patients following stoma‐forming surgery and increases engagement in social aspects of life.ConclusionsIt is important for patients, family members and healthcare professionals to understand the practical and religious implications of stomas on these patients for appropriate guidance and counselling.
Soukup T, Lamb BW, Weigl M, et al., 2019, An Integrated Literature Review of Time-on-Task Effects With a Pragmatic Framework for Understanding and Improving Decision-Making in Multidisciplinary Oncology Team Meetings, FRONTIERS IN PSYCHOLOGY, Vol: 10, ISSN: 1664-1078
- Author Web Link
- Cite
- Citations: 17
Shah TT, Gao C, Peters M, et al., 2019, Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic: results from the Multi-centre cohort study evaluating the role of Inflammatory Markers In patients presenting with acute ureteric Colic (MIMIC) study., BJU Int
OBJECTIVES: To assess the relationship of white blood cell count (WBC) and other routinely collected inflammatory and clinical markers including stone size, stone position, and medical expulsive therapy use (MET), with spontaneous stone passage (SSP) in a large contemporary cohort of patients with acute ureteric colic, as there are conflicting data on the role of WBC and other inflammatory markers in SSP in patients with acute ureteric colic. PATIENTS AND METHODS: Multicentre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (BURST) Research Collaborative at 71 secondary care hospitals across four countries (UK, Republic of Ireland, Australia, and New Zealand). In all, 4170 patients presented with acute ureteric colic and a computed tomography confirmed single ureteric stone. Our primary outcome measure was SSP, as defined by the absence of need for intervention to assist stone passage (SP). Multivariable mixed effects logistic regression was used to explore the relationship between key patient factors and SSP. RESULTS: In all, 2518 patients were discharged with conservative management and had further follow-up with a SSP rate of 74% (n = 1874/2518). Sepsis after discharge with conservative management was reported in 0.6% (n = 16/2518). On multivariable analysis neither WBC, neutrophils count, nor C-reactive protein (CRP) predicted SSP, with an adjusted odds ratio (OR) of 0.97 (95% confidence interval [CI] 0.91-1.04, P = 0.38), 1.06 (95% CI 0.99-1.13, P = 0.1) and 1.00 (95% CI 0.99-1.00, P = 0.17), respectively. MET also did not predict SSP (adjusted OR 1.11, 95% CI 0.76-1.61). However, stone size and stone position were significant predictors. SSP for stones <5 mm was 89% (95% CI 87-90) compared to 49% (95% CI 44-53) for stones ≥5-7 mm, and 29% (95% CI 23-36) for stones >7 mm. For stones in the upper ureter the SSP rate was 52% (95% CI 48-56), midd
Pascoe C, Duncan C, Lamb BW, et al., 2019, Current management of radiation cystitis: a review and practical guide to clinical management, BJU INTERNATIONAL, Vol: 123, Pages: 585-594, ISSN: 1464-4096
- Author Web Link
- Cite
- Citations: 37
Gnanapragasam V, Barrett T, Burling K, et al., 2019, USE OF THE PHI ASSAY AS A FIRST LINE TRIAGING TEST IN AN IMAGE-GUIDED PROSTATE CANCER DIAGNOSTIC PATHWAY. THE PHI IN REFINING MRI STUDY (PRIM), 114th Annual Meeting of the American-Urological-Association (AUA), Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E653-E653, ISSN: 0022-5347
Tan WS, Ahmad A, Feber A, et al., 2019, Development and validation of a haematuria cancer risk score to identify patients at risk of harbouring cancer, JOURNAL OF INTERNAL MEDICINE, Vol: 285, Pages: 436-445, ISSN: 0954-6820
- Author Web Link
- Cite
- Citations: 17
Tan WS, Sarpong R, Khetrapal P, et al., 2019, Does urinary cytology have a role in haematuria investigations?, BJU INTERNATIONAL, Vol: 123, Pages: 74-81, ISSN: 1464-4096
- Author Web Link
- Cite
- Citations: 17
Pascoe C, Christidis D, Manning TG, et al., 2019, Photoselective Vaporization of the Bladder for the Management of Radiation Cystitis-Technique and Initial Outcomes, UROLOGY, Vol: 123, Pages: 295-295, ISSN: 0090-4295
- Author Web Link
- Cite
- Citations: 4
Miah S, Boxall NE, Lamb BW, 2019, Is the educational performance measure a fair way of assessing candidates applying to the United Kingdom Foundation Programme? [Letter], ADVANCES IN MEDICAL EDUCATION AND PRACTICE, Vol: 10, Pages: 591-592, ISSN: 1179-7258
- Author Web Link
- Cite
- Citations: 3
Lamb BW, Rajan P, 2018, The practicing urologists' guide to clinical research, JOURNAL OF CLINICAL UROLOGY, Vol: 11, Pages: 395-397, ISSN: 2051-4158
Warner RM, Bastianpillai C, Lamb BW, et al., 2018, Health services research, JOURNAL OF CLINICAL UROLOGY, Vol: 11, Pages: 357-360, ISSN: 2051-4158
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.