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@article{Adamina:2022:10.1111/codi.16117,
author = {Adamina, M and Ademuyiwa, A and Adisa, A and Bhangu, AA and Bravo, AM and Cunha, MF and Emile, S and Ghosh, D and Glasbey, JC and Harris, B and Keller, D and Lawday, S and Lederhuber, H and Leventoglu, S and Li, E and Modolo, MM and Mittal, R and Mohan, HM and Nepogodiev, D and Parreno-Sacdalan, MD and Pata, F and Pockney, P and Rutegard, M and Simoes, JFF and Smart, N and Varghese, C and Siaw-Acheampong, K and Benson, RA and Bywater, E and Chaudhry, D and Dawson, BE and Evans, JP and Gujjuri, RR and Heritage, E and Jones, CS and Kamarajah, SK and Khatri, C and Khaw, RA and Keatley, JM and Knight, A and Smart, NJ and Minaya-Bravo, A and Gallo, G and Moug, S and Di, Saverio S and Vallance, A and Vimalchandra, D and Griffiths, EA and Evans, RPT and Townen, P and Roberts, K and McKay, S and Isaac, J and Satoi, S and Edwards, J and Coonar, AS and Marchbank, A and Caruana, EJ and Layton, GR and Patel, A and Brunelli, A and Ford, S and Desai, A and Gronchi, A and Fiore, M and Almond, M and T},
doi = {10.1111/codi.16117},
journal = {Colorectal Disease},
pages = {708--726},
title = {The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study},
url = {http://dx.doi.org/10.1111/codi.16117},
volume = {24},
year = {2022}
}

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TY  - JOUR
AB  - AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January–April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90–1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69–1.27, P = 0.672). Longer delays were not associated with poorer outcomes.ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease.
AU  - Adamina,M
AU  - Ademuyiwa,A
AU  - Adisa,A
AU  - Bhangu,AA
AU  - Bravo,AM
AU  - Cunha,MF
AU  - Emile,S
AU  - Ghosh,D
AU  - Glasbey,JC
AU  - Harris,B
AU  - Keller,D
AU  - Lawday,S
AU  - Lederhuber,H
AU  - Leventoglu,S
AU  - Li,E
AU  - Modolo,MM
AU  - Mittal,R
AU  - Mohan,HM
AU  - Nepogodiev,D
AU  - Parreno-Sacdalan,MD
AU  - Pata,F
AU  - Pockney,P
AU  - Rutegard,M
AU  - Simoes,JFF
AU  - Smart,N
AU  - Varghese,C
AU  - Siaw-Acheampong,K
AU  - Benson,RA
AU  - Bywater,E
AU  - Chaudhry,D
AU  - Dawson,BE
AU  - Evans,JP
AU  - Gujjuri,RR
AU  - Heritage,E
AU  - Jones,CS
AU  - Kamarajah,SK
AU  - Khatri,C
AU  - Khaw,RA
AU  - Keatley,JM
AU  - Knight,A
AU  - Smart,NJ
AU  - Minaya-Bravo,A
AU  - Gallo,G
AU  - Moug,S
AU  - Di,Saverio S
AU  - Vallance,A
AU  - Vimalchandra,D
AU  - Griffiths,EA
AU  - Evans,RPT
AU  - Townen,P
AU  - Roberts,K
AU  - McKay,S
AU  - Isaac,J
AU  - Satoi,S
AU  - Edwards,J
AU  - Coonar,AS
AU  - Marchbank,A
AU  - Caruana,EJ
AU  - Layton,GR
AU  - Patel,A
AU  - Brunelli,A
AU  - Ford,S
AU  - Desai,A
AU  - Gronchi,A
AU  - Fiore,M
AU  - Almond,M
AU  - Tirotta,F
AU  - Dumitra,S
AU  - Kolias,A
AU  - Price,SJ
AU  - Fountain,DM
AU  - Jenkinson,MD
AU  - Hutchinson,P
AU  - Marcus,HJ
AU  - Piper,RJ
AU  - Lippa,L
AU  - Servadei,F
AU  - Esene,I
AU  - Freyschlag,C
AU  - Neville,I
AU  - Rosseau,G
AU  - Schaller,K
AU  - Demetriades,AK
AU  - Robertson,F
AU  - Alamri,A
AU  - Shaw,R
AU  - Schache,AG
AU  - Winter,SC
AU  - Ho,M
AU  - Nankivell,P
AU  - Biel,JR
AU  - Batstone,M
AU  - Ganly,I
AU  - Vidya,R
AU  - Wilkins,A
AU  - Singh,JK
AU  - Thekinkattil,D
AU  - Sundar,S
AU  - Fotopoulou,C
AU  - Leung,EY
AU  - Khan,T
AU  - Chiva,L
AU  - Sehouli,J
AU  - Fagotti,A
AU  - Cohen,P
AU  - Gutelkin,M
AU  - Ghebre,R
AU  - Konney,T
AU  - Pareja,R
AU  - Bristow,R
AU  - Dowdy,S
AU  - Shylasree,TS
AU  - Seenivasagam,RK
AU  - Ng,J
AU  - Fujiwar,K
AU  - Stewart,GD
AU  - Lamb,B
AU  - Narahari,K
AU  - McNeill,A
AU  - Colquhoun,A
AU  - McGrath,JS
AU  - Bromage,S
AU  - Barod,R
AU  - Kasivisvanathan,V
AU  - Klatte,T
AU  - Abbott,TEF
AU  - Abukhalaf,S
AU  - Ademuyiwa,AO
AU  - Agarwal,A
AU  - Akkulak,M
AU  - Alameer,E
AU  - Alderson,D
AU  - Alakaloko,F
AU  - Albertsmeier,M
AU  - Alser,O
AU  - Alshaar,M
AU  - Alshryda,S
AU  - Arnaud,AP
AU  - Augestad,KM
AU  - Ayasra,F
AU  - Azevedo,J
AU  - Bankhead-Kendall,BK
AU  - Barlow,E
AU  - Beard,D
AU  - Blanco-Colino,R
AU  - Brar,A
AU  - Breen,KA
AU  - Bretherton,C
AU  - Buarque,IL
AU  - Burke,J
AU  - Chaar,M
AU  - Chakrabortee,S
AU  - Christensen,P
AU  - Cox,D
AU  - Cukier,M
AU  - Davidson,GH
AU  - Drake,TM
AU  - Edwards,JG
AU  - Elhadi,M
AU  - Farik,S
AU  - Fitzgerald,JE
AU  - Garmanova,T
AU  - Gomes,GMA
AU  - Grecinos,G
AU  - Gruendl,M
AU  - Halkias,C
AU  - Harrison,EM
AU  - Hisham,I
AU  - Hutchinson,PJ
AU  - Hwang,S
AU  - Isik,A
AU  - Jonker,P
AU  - Kaafarani,HMA
AU  - Kruijff,S
AU  - Lawani,I
AU  - Litvin,A
AU  - Loehrer,A
AU  - Lof
DO  - 10.1111/codi.16117
EP  - 726
PY  - 2022///
SN  - 1462-8910
SP  - 708
TI  - The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
T2  - Colorectal Disease
UR  - http://dx.doi.org/10.1111/codi.16117
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000789560800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/codi.16117
UR  - http://hdl.handle.net/10044/1/100246
VL  - 24
ER  -

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