Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Senior Lecturer



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BibTex format

author = {Berthelot, M and Henry, FP and Hunter, J and Leff, D and Wood, S and Jallali, N and Dex, E and Ladislava, L and Lo, B and Yang, GZ},
doi = {10.1117/1.JBO.24.6.067001},
journal = {Journal of Biomedical Optics},
pages = {067001--1--067001--8},
title = {Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report},
url = {},
volume = {24},
year = {2019}

RIS format (EndNote, RefMan)

AB - Free tissue transfer (FTT) surgery for breast reconstruction following mastectomy has become a routineoperation with high success rates. Although failure is low, it can have a devastating impact on patient recovery,prognosis and psychological well-being. Continuous and objective monitoring of tissue oxygen saturation (StO2) hasshown to reduce failure rates through rapid detection time of postoperative vascular complications. We have developeda pervasive wearable wireless device that employs near infrared spectroscopy (NIRS) to continuously monitor FTTviaStO2measurement. Previously tested on different models, this paper introduces the results of a clinical study. Thegoal of the study is to demonstrate the developed device can reliably detectStO2variations in a clinical setting: 14patients were recruited. Advanced data analysis were performed on theStO2variations, the relativeStO2gradientchange, and, the classification of theStO2within different clusters of blood occlusion level (from 0% to 100% at 25%step) based on previous studies made on a vascular phantom and animals. The outcomes of the clinical study concurwith previous experimental results and the expected biological responses. This suggests the device is able to correctlydetect perfusion changes and provide real-time assessment on the viability of the FTT in a clinical setting.
AU - Berthelot,M
AU - Henry,FP
AU - Hunter,J
AU - Leff,D
AU - Wood,S
AU - Jallali,N
AU - Dex,E
AU - Ladislava,L
AU - Lo,B
AU - Yang,GZ
DO - 10.1117/1.JBO.24.6.067001
EP - 1
PY - 2019///
SN - 1083-3668
SP - 067001
TI - Pervasive wearable device for free tissue transfer monitoring based on advanced data analysis: clinical study report
T2 - Journal of Biomedical Optics
UR -
UR -
UR -
VL - 24
ER -