Imperial College London
Dr Bethan Davies

DrBethanDavies

Faculty of Medicine, School of Public Health

Clinical Senior Lecturer in Epidemiology
 
 
 
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Contact

 

bethan.davies06

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davies:2014:infdis/jiu483,
author = {Davies, B and Ward, H and Leung, S and Turner, KME and Garnett, GP and Blanchard, JF and Yu, BN},
doi = {infdis/jiu483},
journal = {Journal of Infectious Diseases},
pages = {S549--S555},
title = {Heterogeneity in Risk of Pelvic Inflammatory Diseases After Chlamydia Infection: A Population-Based Study in Manitoba, Canada},
url = {http://dx.doi.org/10.1093/infdis/jiu483},
volume = {210},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background. The association between chlamydia infection and pelvic inflammatory disease (PID) is a key parameterfor models evaluating the impact of chlamydia control programs. We quantified this association using aretrospective population-based cohort.Methods. We used administrative health data sets to construct a retrospective population-based cohort ofwomen and girls aged 12–24 years who were resident in Manitoba, Canada, between 1992 and 1996. We performedsurvival analysis on a subcohort of individuals who were tested for chlamydia to estimate the risk of PID diagnosed ina primary care, outpatient, or inpatient setting after ≥1 positive chlamydia test.Results. A total of 73 883 individuals contributed 625 621 person years of follow-up. Those with a diagnosis ofchlamydia had an increased risk of PID over their reproductive lifetime compared with those who tested negative(adjusted hazard ratio [AHR], 1.55; 95% confidence interval [CI], 1.43–1.70). This risk increased with each subsequentinfection: the AHR was 1.17 for first reinfection (95% CI, 1.06–1.30) and 1.35 for the second (95% CI,1.04–1.75). The increased risk of PID from reinfection was highest in younger individuals (AHR, 4.55 (95% CI,3.59–5.78) in individuals aged 12–15 years at the time of their second reinfection, compared with individualsolder than 30 years).Conclusions. There is heterogeneity in the risk of PID after a chlamydia infection. Describing the progression toPID in mathematical models as an average rate may be an oversimplification; more accurate estimates of the costeffectivenessof screening may be obtained by using an individual-based measure of risk. Health inequalities may bereduced by targeting health promotion interventions at sexually active girls younger than 16 years and those with ahistory of chlamydia.
AU  - Davies,B
AU  - Ward,H
AU  - Leung,S
AU  - Turner,KME
AU  - Garnett,GP
AU  - Blanchard,JF
AU  - Yu,BN
DO  - infdis/jiu483
EP  - 555
PY  - 2014///
SN  - 1537-6613
SP  - 549
TI  - Heterogeneity in Risk of Pelvic Inflammatory Diseases After Chlamydia Infection: A Population-Based Study in Manitoba, Canada
T2  - Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jiu483
UR  - http://hdl.handle.net/10044/1/24608
VL  - 210
ER  -
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