Imperial College London

DrBhavikPatel

Faculty of EngineeringDepartment of Bioengineering

Visiting Researcher
 
 
 
//

Contact

 

+44 (0)20 7594 6498bhavik.a.patel Website

 
 
//

Location

 

438Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

182 results found

Noriega N, Shekhirev M, Shuck CE, Salvage J, VahidMohammadi A, Dymond MK, Lacey J, Sandeman S, Gogotsi Y, Patel BAet al., 2024, Pristine Ti3C2Tx MXene Enables Flexible and Transparent Electrochemical Sensors., ACS Appl Mater Interfaces, Vol: 16, Pages: 6569-6578

In the era of the internet of things, there exists a pressing need for technologies that meet the stringent demands of wearable, self-powered, and seamlessly integrated devices. Current approaches to developing MXene-based electrochemical sensors involve either rigid or opaque components, limiting their use in niche applications. This study investigates the potential of pristine Ti3C2Tx electrodes for flexible and transparent electrochemical sensing, achieved through an exploration of how material characteristics (flake size, flake orientation, film geometry, and uniformity) impact the electrochemical activity of the outer sphere redox probe ruthenium hexamine using cyclic voltammetry. The optimized electrode made of stacked large Ti3C2Tx flakes demonstrated excellent reproducibility and resistance to bending conditions, suggesting their use for reliable, robust, and flexible sensors. Reducing electrode thickness resulted in an amplified faradaic-to-capacitance signal, which is advantageous for this application. This led to the deposition of transparent thin Ti3C2Tx films, which maintained their best performance up to 73% transparency. These findings underscore its promise for high-performance, tailored sensors, marking a significant stride in advancing MXene utilization in next-generation electrochemical sensing technologies. The results encourage the analytical electrochemistry field to take advantage of the unique properties that pristine Ti3C2Tx electrodes can provide in sensing through more parametric studies.

Journal article

Miller C, Keattch O, Shergill RS, Patel BAet al., 2024, Evaluating diverse electrode surface patterns of 3D printed carbon thermoplastic electrochemical sensors., Analyst

Electrochemical sensing techniques rely on redox reactions taking place at the electrode surface. The configuration of this surface is of the utmost importance in the advancement of electrochemical sensors. The majority of previous electrode manufacturing methods, including 3D printing have produced electrodes with flat surfaces. There is a distinct potential for 3D printing to create intricate and distinctive electrode surface shapes. In the proposed work, 3D printed carbon black polylactic acid electrodes with nine different surface morphologies were made. These were compared to a flat surface electrode. To evaluate the performance of the electrodes, measurements were conducted in three different redox probes (ferrocene methanol, ferricyanide, and dopamine). Our findings highlighted that when electrodes were normalised for the geometric surface area of the electrode, the surface pattern of the electrode surface can impact the observed current and electron transfer kinetics. Electrodes that had a dome and flag pattern on the electrode surface showed the highest oxidation currents and had lower values for the difference between the anodic and cathodic peak current (ΔE). However, designs with rings had lower current values and higher ΔE values. These differences are most likely due to variations in the accessibility of conductive sites on the electrode surface due to the varying surface roughness of different patterned designs. Our findings highlight that when making electrodes using 3D printing, surface patterning of the electrode surface can be used as an effective approach to enhance the performance of the sensor for varying applications.

Journal article

Shergill RS, Bhatia P, Johnstone L, Patel BAet al., 2024, Eco-Friendly Approach to Making 3D-Printed Electrochemical Sensors, ACS Sustainable Chemistry and Engineering, Vol: 12, Pages: 416-422

Carbon poly(lactic acid) (PLA)-based 3D-printed electrodes have demonstrated their effectiveness across a diverse spectrum of applications. Nonetheless, the issue of the inadequate natural biodegradability of PLA raises significant sustainability concerns, given the predominate single-use nature of 3D-printed electrochemical sensors. Our study is centered on a systematic approach to understand if reducing the amount of carbon black (CB)/PLA used to make the electrodes can have a significant impact on their performance. CB/PLA electrodes were made with varying amounts of material infill and assessed using cyclic voltammetry with different redox probes. Our findings showcased that there is no difference in the anodic current and electron transfer kinetics of CB/PLA electrodes made using infills from 30% to 100%. When comparing the sensing capabilities of 30% and 100% infill electrodes, no differences were observed in the sensitivity and limit of detection for the measurement of dopamine. Using 30% infill to make electrodes reduces CB/PLA usage by 44%. This approach is of significant utility for the development of 3D-printed electrochemical sensors for a broad range of applications spanning sensing and energy storage. Importantly, this manufacturing approach reduces the use of thermoplastics, which can provide considerable benefits to the environment.

Journal article

Patel BA, 2023, Being Efficient: What Are Acceptable Timeframes for Completing Basic Laboratory Practical Procedures?, JOURNAL OF CHEMICAL EDUCATION, Vol: 100, Pages: 3873-3880, ISSN: 0021-9584

Journal article

Shergill RS, Patel BA, 2023, Preprinting Saponification of Carbon Thermoplastic Filaments Provides Ready-to-Use Electrochemical Sensors, ACS APPLIED ELECTRONIC MATERIALS, Vol: 5, Pages: 5120-5128

Journal article

Badrie R, MacDonnell J, Patel BA, 2023, Barriers to pursing postgraduate research study among final year undergraduate minority ethnic students at a post-1992 UK university, Equity in Education & Society, Vol: 2, Pages: 206-222, ISSN: 2752-6461

<jats:p> Minority ethnic students are well represented in undergraduate and postgraduate taught study, but over a sustained period, representation in postgraduate research (PGR) study has been significantly lower. Various barriers to participation in PGR study have been suggested, however, it is not clear if these barriers are similar across different hierarchies of higher education institution within the UK. Our study explored specifically the perceived barriers that may exist towards PGR study for minority ethnic students at a post-1992 university. Our findings showed that one third of minority ethnic students did not learn about PGR study. To gain more insight into PGR study, minority ethnic students would approach academic staff. The perceived key barriers to participation in PGR study were associated with understanding the application process and feeling if they would not be selected by a research-intensive university. To address these barriers, the solutions that were proposed where to have PGR role models which can provide mentorship on the application process and highlight the career benefits of conducting PGR study. Our findings provide vital insight into key challenges faced by minority ethnic students at a post-1992 university and help identify approaches which can be implemented to address these barriers. </jats:p>

Journal article

Tough IR, Lund ML, Patel BA, Schwartz TW, Cox HMet al., 2023, Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine, NEUROGASTROENTEROLOGY AND MOTILITY, Vol: 35, ISSN: 1350-1925

Journal article

Slate AJ, Clarke OE, Kerio M, Nzakizwanayo J, Patel BA, Jones Bet al., 2023, Infection responsive coatings to reduce biofilm formation and encrustation of urinary catheters, JOURNAL OF APPLIED MICROBIOLOGY, Vol: 134, ISSN: 1364-5072

Journal article

Hussain KK, Shergill RS, Hamzah HH, Yeoman MS, Patel BAet al., 2023, Exploring Different Carbon Allotrope Thermoplastic Composites for Electrochemical Sensing, ACS APPLIED POLYMER MATERIALS, Vol: 5, Pages: 4136-4145, ISSN: 2637-6105

Journal article

Brooks EL, Hussain KK, Kotecha K, Abdalla A, Patel BAet al., 2023, Three-Dimensional-Printed Electrochemical Multiwell Plates for Monitoring Food Intolerance from Intestinal Organoids, ACS SENSORS, Vol: 8, Pages: 712-720, ISSN: 2379-3694

Journal article

Perez F, Kotecha N, Lavoie B, Mawe GM, Patel BAet al., 2023, Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation, CHEMBIOCHEM, Vol: 24, ISSN: 1439-4227

Journal article

Shergill RS, Miller CL, Patel BA, 2023, Influence of instrument parameters on the electrochemical activity of 3D printed carbon thermoplastic electrodes, SCIENTIFIC REPORTS, Vol: 13, ISSN: 2045-2322

Journal article

Islam MK, Hossain MM, Patel BA, 2023, Comparing the perceptions of students, academic and support staff when reflecting on person and online lectures in Bangladesh, Innovations in Education and Teaching International, ISSN: 1470-3297

The COVID pandemic forced higher educational institutions to transition from in-person lectures to online lectures. In Bangladesh, this transition was steep, with no prior experience of this mode of delivery. This study aimed to understand and compare the experiences of students, academic staff and support staff within the area of veterinary science in Bangladesh, when comparing in-person and online lectures. We conducted a mixed methods survey to learn about the perceived experiences, strengths and limitations of each mode of teaching from students and staff. Our findings highlighted that students, academic staff and support staff all preferred in-person lectures when compared to online lectures. However, the extent of preference varied, with support staff strongly favouring the in-person mode of delivery, followed by academic staff and then students. Overall, these findings are essential to aid policymakers and university authorities on some of the strengths and barriers of in-person and online lectures.

Journal article

Aydogdu O, Perez F, Rataj J, Nilsson F, Aronsson P, Carlsson T, Sandner P, Patel B, Tobin G, Winder Met al., 2022, Treatment with the soluble guanylate cyclase activator BAY 60-2770 restores in vitro bladder contractile responses in a rat model of chronic prostatitis, Continence, Vol: 4

Aim: Examine how innate bladder contractility and corresponding receptor expression was affected by chronic prostatitis (CP) and how treatment with the soluble guanylate cyclase (sGC) activator BAY 60-2770 influenced this. Methods: To create a functional model for CP, 24 male Sprague-Dawley rats were intraprostatically injected with either zymosan or saline, serving as control. After a recovery period, the rats were treated with either BAY 60-2770 or dimethyl sulfoxide (DMSO; vehicle) on days 8–20. Urine samples were collected for measurement of ATP. On day 21, the bladder was excised and contractile responses to electrical field stimulation (EFS), methacholine, ATP and nitric oxide (NO) were examined in an in vitro organ bath. Subsequently, the expression of purinergic (P2X1 & P2X3) and muscarinic (M3) receptors as well as sGC was examined immunohistochemically. Results: Induction of CP led to significantly attenuated purinergic bladder contractions, which were normalized by treatment with BAY 60-2770. Induction of CP did not alter the contractile bladder responses to EFS, methacholine or NO. However, treatment with BAY 60-2770 led to significantly increased contractile bladder responses to EFS and MeCh and significantly enhanced relaxatory nitrergic responses. There were no significant differences between the groups regarding purinergic or cholinergic receptor expression, however treatment with BAY 60-2770 led to attenuated expression of sGC in the urothelium. Conclusion: Taken together, these findings indicate that drugs targeting the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway may be a promising option to restore alterations in bladder contractility that arise due to CP.

Journal article

Brooks E, Hussain K, Kotecha K, Abdalla A, Patel Bet al., 2022, 3D Printed Electrochemical Multiwell Plate for Monitoring Food Intolerance from Intestinal Organoids

<jats:p>Common symptoms of food intolerance are caused by chemical components within food that have a pharmacological activity to alter the motility of the gastrointestinal tract. Food intolerance is difficult to diagnose as it requires a long-term process of eliminating foods that are responsible for gastrointestinal symptoms. Enterochromaffin (EC) cells are key intestinal epithelium cells that respond to luminal chemical stimulants by releasing 5-HT. Changes in 5-HT levels have been shown to directly alter the motility of the intestinal tract. Therefore, a rapid approach for monitoring the impact of chemicals in food components on 5-HT levels can provide a personalised insight into food intolerance and help stratify diets. Within this study we developed a 3D printed electrochemical multiwell plate to determine changes in 5-HT levels from intestinal organoids that were exposed to varying chemical components found in food. The carbon black/poly-lactic acid (CB/PLA) electrodes had a linear range in physiological concentrations of 5-HT (0.1 – 2µM) with a limit of detection of 0.07 µM. The electrodes were stable for monitoring 5-HT overflow from intestinal organoids. Using the electrochemical multiwell plate containing intestinal organoids, increases in 5-HT were observed in the presence of 0.1 mM cinnamaldehyde and 10 mM quercetin but reduction in 5-HT levels was observed in 1 mM sorbitol when compared to control. These changes in the presence of chemicals commonly found in food were verified with ex vivo ileum tissue measurements using chromatography and amperometry with boron-doped diamond electrodes. Overall, our 3D electrochemical multiwell plate measurements with intestinal organoids highlight an approach that can be a high-throughput platform technology for rapid screening of food intolerance to provide personalised nutritional diet.</jats:p>

Journal article

Patel BA, 2022, A Chemical Analysis Laboratory Class Solely Assessed on the Accuracy and Precision of Student Data, JOURNAL OF CHEMICAL EDUCATION, Vol: 99, Pages: 3585-3589, ISSN: 0021-9584

Journal article

Shergill RS, Patel BA, 2022, The Effects of Material Extrusion Printing Speed on the Electrochemical Activity of Carbon Black/Polylactic Acid Electrodes, CHEMELECTROCHEM, Vol: 9, ISSN: 2196-0216

Journal article

Aydogdu O, Perez F, Aronsson P, Gocun PU, Carlsson T, Sandner P, Patel B, Winder Met al., 2022, Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder function in an in vivo rat model of chronic prostatitis, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 927, ISSN: 0014-2999

Journal article

Shergill R, Patel B, 2022, The effects of material extrusion printing speed on the conductivity of carbon black/polylactic acid electrodes

<jats:p>Material extrusion printing process can make electrodes and electronic components at any geometry and has provided a reproducible approach towards the fabrication of conductive carbon thermoplastic composite parts. Printing parameters can have a significant influence on the conductivity of the printed part, however limited studies have focused on understanding the impact of printing parameters. Our study explored the influence of printing speed on the conductivity of 3D printed carbon black/polylactic acid (CB/PLA) electrodes. We made CB/PLA at print speeds ranging from 20 to 100 mm/s and evaluated the performance of these electrodes using inner and outer sphere redox probes and through imaging. Electrodes made using 60 mm/s printing speed had the greatest electrochemical activity. Electrodes made using higher and lower printing speeds were more resistive. This study is the first to demonstrate the significant impact that printing speed can have on the conductivity of 3D printed CB/PLA electrodes. The implications of this study are important when defining the 3D printing manufacturing process of electrodes and electronic components.</jats:p>

Journal article

Patel BA, 2022, Threading career skills into classrooms, NATURE REVIEWS CHEMISTRY, Vol: 6, Pages: 237-238

Journal article

Shergill RS, Farlow A, Perez F, Patel BAet al., 2022, 3D-printed electrochemical pestle and mortar for identification of falsified pharmaceutical tablets, MICROCHIMICA ACTA, Vol: 189, ISSN: 0026-3672

Journal article

Shergill RS, Perez F, Abdalla A, Patel BAet al., 2022, Comparing electrochemical pre-treated 3D printed native and mechanically polished electrode surfaces for analytical sensing, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 905, ISSN: 1572-6657

Journal article

Miller CL, Kristova P, Patel BA, 2022, Detection of vitamin C in various falsified oral formulations using voltammetry, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 904, ISSN: 1572-6657

Journal article

Ponikwer F, Dunskute U, Rafique R, Patel BAet al., 2022, How do different communities of pharmacy students in the United Kingdom approach study and personal support?, PHARMACY EDUCATION, Vol: 22, Pages: 584-594, ISSN: 1560-2214

Journal article

Abdalla A, Jones W, Flint MS, Patel BAet al., 2021, Bicomponent composite electrochemical sensors for sustained monitoring of hydrogen peroxide in breast cancer cells, ELECTROCHIMICA ACTA, Vol: 398, ISSN: 0013-4686

Journal article

Shergill RS, Kristova P, Patel BA, 2021, Detection of falsified clopidogrel in the presence of excipients using voltammetry, ANALYTICAL METHODS, Vol: 13, Pages: 5335-5342, ISSN: 1759-9660

Journal article

Wang Y, Gu C, Patel BA, Ewing AGet al., 2021, Nano‐analysis Reveals High Fraction of Serotonin Release during Exocytosis from a Gut Epithelium Model Cell, Angewandte Chemie, Vol: 133, Pages: 23744-23748, ISSN: 0044-8249

<jats:title>Abstract</jats:title><jats:p>Electrochemical methods were used to explore the exocytotic nature of serotonin (5‐HT) release in human carcinoid BON cells, an in vitro human enterochromaffin cell model, to understand the mechanisms operating the release of gut‐derived 5‐HT in the intestinal mucosal epithelium. We show that the fractional vesicular 5‐HT release in BON cells is 80 % compared to previous work in pancreatic beta cells (34 %). The fractional release increased from 80 % in control BON cells to 87 % with 5‐HT preincubation and nearly 100 % with the combination of 5‐HT and the 5‐HT<jats:sub>4</jats:sub> autoreceptor agonist, cisapride. Thus, partial release is the primary mechanism of exocytosis in BON cells, resulting in a variable amount of the vesicular content being released. Factors that control secretion of 5‐HT from enterochromaffin cells or BON cells are important as partial release provides a mechanism for development of effective therapeutic strategies to treat gastrointestinal diseases.</jats:p>

Journal article

Wang Y, Gu C, Patel BA, Ewing AGet al., 2021, Nano-analysis Reveals High Fraction of Serotonin Release during Exocytosis from a Gut Epithelium Model Cell, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 60, Pages: 23552-23556, ISSN: 1433-7851

Journal article

Ponikwer F, Patel BA, 2021, Work-Integrated Learning: A Game-Based Learning Activity That Enhances Student Employability, JOURNAL OF CHEMICAL EDUCATION, Vol: 98, Pages: 888-895, ISSN: 0021-9584

Journal article

Morgan LD, Mohammed A, Patel BA, Arundell M, Jennert-Burtson K, Hernadi L, Overall A, Bowler LD, O'Hare D, Yeoman MSet al., 2021, Decreased 14-3-3 expression correlates with age-related regional reductions in CNS dopamine and motor function in the pond snail, <i>Lymnaea</i>, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 53, Pages: 1394-1411, ISSN: 0953-816X

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00382053&limit=30&person=true