Imperial College London

DrBhavikPatel

Faculty of EngineeringDepartment of Bioengineering

Visiting Researcher
 
 
 
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Contact

 

+44 (0)20 7594 6498bhavik.a.patel Website

 
 
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Location

 

438Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

163 results found

Brooks EL, Hussain KK, Kotecha K, Abdalla A, Patel BAet al., 2023, Three-Dimensional-Printed Electrochemical Multiwell Plates for Monitoring Food Intolerance from Intestinal Organoids., ACS Sens, Vol: 8, Pages: 712-720

Common symptoms of food intolerance are caused by chemical components within food that have a pharmacological activity to alter the motility of the gastrointestinal tract. Food intolerance is difficult to diagnose as it requires a long-term process of eliminating foods that are responsible for gastrointestinal symptoms. Enterochromaffin (EC) cells are key intestinal epithelium cells that respond to luminal chemical stimulants by releasing 5-HT. Changes in 5-HT levels have been shown to directly alter the motility of the intestinal tract. Therefore, a rapid approach for monitoring the impact of chemicals in food components on 5-HT levels can provide a personalized insight into food intolerance and help stratify diets. Within this study, we developed a three-dimensional (3D)-printed electrochemical multiwell plate to determine changes in 5-HT levels from intestinal organoids that were exposed to varying chemical components found in food. The carbon black/poly-lactic acid (CB/PLA) electrodes had a linear range in physiological concentrations of 5-HT (0.1-2 μM) with a limit of detection of 0.07 μM. The electrodes were stable for monitoring 5-HT overflow from intestinal organoids. Using the electrochemical multiwell plate containing intestinal organoids, increases in 5-HT were observed in the presence of 0.1 mM cinnamaldehyde and 10 mM quercetin but reduction in 5-HT levels was observed in 1 mM sorbitol when compared to control. These changes in the presence of chemicals commonly found in food were verified with ex vivo ileum tissue measurements using chromatography and amperometry with boron-doped diamond electrodes. Overall, our 3D electrochemical multiwell plate measurements with intestinal organoids highlight an approach that can be a high-throughput platform technology for rapid screening of food intolerance to provide personalized nutritional diet.

Journal article

Perez F, Kotecha N, Lavoie B, Mawe GM, Patel BAet al., 2023, Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation, CHEMBIOCHEM, Vol: 24, ISSN: 1439-4227

Journal article

Shergill RS, Miller CL, Patel BA, 2023, Influence of instrument parameters on the electrochemical activity of 3D printed carbon thermoplastic electrodes., Sci Rep, Vol: 13

3D printing provides a reliable approach for the manufacture of carbon thermoplastic composite electrochemical sensors. Many studies have explored the impact of printing parameters on the electrochemical activity of carbon thermoplastic electrodes but limited is known about the influence of instrument parameters, which have been shown to alter the structure and mechanical strength of 3D printed thermoplastics. We explored the impact of extruder temperature, nozzle diameter and heated bed temperature on the electrochemical activity of carbon black/poly-lactic acid (CB/PLA) electrodes. Cyclic voltammetry and electrochemical impedance spectroscopy measurements were conducted using standard redox probes. The electrode surface and cross-section of the electrode was visualised using scanning electron microscopy. We found that using extruder temperatures of 230 °C and 240 °C improved the electrochemical activity of CB/PLA electrodes, due to an increase in surface roughness and a reduction in the number of voids in-between print layers. Nozzle diameter, heated bed temperature of different 3D printers did not impact the electrochemical activity of CB/PLA electrodes. However high-end printers provide improved batch reproducibility of electrodes. These findings highlight the key instrument parameters that need to be considered when manufacturing carbon thermoplastic composite electrochemical sensors when using 3D printing.

Journal article

Aydogdu O, Perez F, Rataj J, Nilsson F, Aronsson P, Carlsson T, Sandner P, Patel B, Tobin G, Winder Met al., 2022, Treatment with the soluble guanylate cyclase activator BAY 60-2770 restores in vitro bladder contractile responses in a rat model of chronic prostatitis, Continence, Vol: 4, Pages: 100520-100520, ISSN: 2772-9737

Journal article

Patel BA, 2022, A Chemical Analysis Laboratory Class Solely Assessed on the Accuracy and Precision of Student Data, JOURNAL OF CHEMICAL EDUCATION, Vol: 99, Pages: 3585-3589, ISSN: 0021-9584

Journal article

Aydogdu O, Perez F, Aronsson P, Gocun PU, Carlsson T, Sandner P, Patel B, Winder Met al., 2022, Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder function in an in vivo rat model of chronic prostatitis, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 927, ISSN: 0014-2999

Journal article

Patel BA, 2022, Threading career skills into classrooms, NATURE REVIEWS CHEMISTRY, Vol: 6, Pages: 237-238

Journal article

Shergill RS, Farlow A, Perez F, Patel BAet al., 2022, 3D-printed electrochemical pestle and mortar for identification of falsified pharmaceutical tablets, MICROCHIMICA ACTA, Vol: 189, ISSN: 0026-3672

Journal article

Shergill RS, Perez F, Abdalla A, Patel BAet al., 2022, Comparing electrochemical pre-treated 3D printed native and mechanically polished electrode surfaces for analytical sensing, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 905, ISSN: 1572-6657

Journal article

Ponikwer F, Dunskute U, Rafique R, Patel BAet al., 2022, How do different communities of pharmacy students in the United Kingdom approach study and personal support?, PHARMACY EDUCATION, Vol: 22, Pages: 584-594, ISSN: 1560-2214

Journal article

Miller CL, Kristova P, Patel BA, 2021, Detection of vitamin C in various falsified oral formulations using voltammetry, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 904, ISSN: 1572-6657

Journal article

Wang Y, Gu C, Patel BA, Ewing AGet al., 2021, Nano‚Äźanalysis Reveals High Fraction of Serotonin Release during Exocytosis from a Gut Epithelium Model Cell, Angewandte Chemie, Vol: 133, Pages: 23744-23748, ISSN: 0044-8249

Journal article

Shergill RS, Kristova P, Patel BA, 2021, Detection of falsified clopidogrel in the presence of excipients using voltammetry, ANALYTICAL METHODS, Vol: 13, Pages: 5335-5342, ISSN: 1759-9660

Journal article

Abdalla A, Jones W, Flint MS, Patel BAet al., 2021, Bicomponent composite electrochemical sensors for sustained monitoring of hydrogen peroxide in breast cancer cells, ELECTROCHIMICA ACTA, Vol: 398, ISSN: 0013-4686

Journal article

Wang Y, Gu C, Patel BA, Ewing AGet al., 2021, Nano-analysis Reveals High Fraction of Serotonin Release during Exocytosis from a Gut Epithelium Model Cell, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 60, Pages: 23552-23556, ISSN: 1433-7851

Journal article

Abdalla A, Perez F, Canadas AT, Ray S, Patel BAet al., 2021, How normalisation factors influence the interpretations of 3D-printed sensors for electroanalysis, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 881, ISSN: 1572-6657

Journal article

Ponikwer F, Patel BA, 2021, Work-Integrated Learning: A Game-Based Learning Activity That Enhances Student Employability, JOURNAL OF CHEMICAL EDUCATION, Vol: 98, Pages: 888-895, ISSN: 0021-9584

Journal article

Hamzah HH, Saleh NH, Patel BA, Mahat MM, Shafiee SA, Sonmez Tet al., 2021, Recycling Chocolate Aluminum Wrapping Foil as to Create Electrochemical Metal Strip Electrodes, MOLECULES, Vol: 26

Journal article

Abdalla A, Patel BA, 2021, 3D Printed Electrochemical Sensors, ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 14, 2021, Vol: 14, Pages: 47-63, ISSN: 1936-1327

Journal article

Morgan LD, Mohammed A, Patel BA, Arundell M, Jennert-Burtson K, Hernadi L, Overall A, Bowler LD, O'Hare D, Yeoman MSet al., 2020, Decreased 14-3-3 expression correlates with age-related regional reductions in CNS dopamine and motor function in the pond snail, Lymnaea, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 53, Pages: 1394-1411, ISSN: 0953-816X

Journal article

Panossian A, Cave MW, Patel BA, Brooks EL, Flint MS, Yeoman MSet al., 2020, Effects of age and social isolation on murine hippocampal biochemistry and behavior, MECHANISMS OF AGEING AND DEVELOPMENT, Vol: 191, ISSN: 0047-6374

Journal article

Rajan TS, Read TL, Abdalla A, Patel BA, Macpherson Jet al., 2020, Ex Vivo Electrochemical pH Mapping of the Gastrointestinal Tract in the Absence and Presence of Pharmacological Agents, ACS SENSORS, Vol: 5, Pages: 2858-2865, ISSN: 2379-3694

Journal article

Abdalla A, Hamzah HH, Keattch O, Covill D, Patel BAet al., 2020, Augmentation of conductive pathways in carbon black/PLA 3D-printed electrodes achieved through varying printing parameters, ELECTROCHIMICA ACTA, Vol: 354, ISSN: 0013-4686

Journal article

Herrmann M, Abdalla A, Patel BA, 2020, Potassium Concentration Alters Calibration Sensitivities of Dopamine but not Serotonin, ELECTROANALYSIS, Vol: 33, Pages: 1-5, ISSN: 1040-0397

Journal article

Baldwin F, Gray R, Boyd O, Waxman D, Patel B, Allen M, Scutt Get al., 2020, Safe prognostication following cardiac arrest: The role of the pharmacokinetics of fentanyl in patients treated with targeted temperature management, RESUSCITATION, Vol: 149, Pages: 10-16, ISSN: 0300-9572

Journal article

Kirupakaran K, de Sousa P, Le Roux C, Redwood L, Rabe H, Patel BAet al., 2020, Evaluation of the causal effects between dopamine infusion changeover and fluctuations in mean arterial pressure in neonates, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 105, Pages: 390-394, ISSN: 0003-9888

Journal article

Abdalla A, Patel BA, 2020, 3D-printed electrochemical sensors: A new horizon for measurement of biomolecules, CURRENT OPINION IN ELECTROCHEMISTRY, Vol: 20, Pages: 78-81, ISSN: 2451-9103

Journal article

Patel B, Perez F, Aronsson P, Alothmani R, Carlsson T, Winder Met al., 2020, Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis, PHARMACOLOGY RESEARCH & PERSPECTIVES, Vol: 8, ISSN: 2052-1707

Journal article

Brooks EL, Mutengwa VS, Abdalla A, Yeoman MS, Patel BAet al., 2019, Determination of tryptophan metabolism from biological tissues and fluids using high performance liquid chromatography with simultaneous dual electrochemical detection, ANALYST, Vol: 144, Pages: 6011-6018, ISSN: 0003-2654

Journal article

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