Summary
I am a leading exponent internationally of the “Learning Health System’ (LHS) concept. Although my initial training in research was in heath technology assessment, real-world (pragmatic) clinical trials and clinical research in Family Medicine, since 2003 I have worked in the area of Clinical Informatics, being appointed to a Chair in Medical Informatics at Imperial in 2015 and elected one of the first 100 founding fellows of the new UK Faculty of Clinical Informatics in 2017. I have had wide exposure to European and US clinical informatics through workshops and symposia.
I was the UK lead investigator on an NIH Clinical Research Roadmap project (The Electronic Primary Care Research Network. HHS268N200425212C) 2006-10. From 2010-15 I led a €9million EU FP7 programme, ‘TRANSFoRm: Patient Safety and Translational Research in Europe’.
TRANSFoRm set about using ontologies, data standards and models to create a common infrastructure for the LHS with three specific use cases (eSource for clinical trials, phenomics and clinical diagnosis.
Prior to moving to Imperial I was Wolfson Professor of General Practice at King's College London. At Imperial, I work in the Institute of Global Health Innovation, with research in Artificial Intelligence, cancer diagnosis and learning systems, eSource for clinical trials and global eHealth. I sit on the Cancer Research UK Population research funding panel and the Medical Research Council Methodology Research panel.
Currently there are three areas of active research:
1. LHS and guidelines. Completing the LHS cycle with a computational infrastructure for deploying guidelines as decision support linked to the EHR. Currently supported as an EPSRC Global Health Development Project (www.ROAD2H.org).
2. Establishing a LHS for diagnosis. Currently moving from a prototype evaluated in a rich simulation to deployment in practices. Funded by CRUK.
3. Developing a clinical prediction rule for the risk of admission/death in acute Covid in Primary care. RECAP - funded by the Community Jameel Imperial College Covid-19 Excellence fund (and collaborating with Oxford University). RECAP
Publications
Journals
Delaney BC, Rayner C, Freyer A, et al., 2022, Author response., Br J Gen Pract, Vol:72, Pages:259-260
Meza-Torres B, Delanerolle G, Okusi C, et al., 2022, Differences in clinical presentation with long covid following community and hospital infection, and associations with all-cause mortality: English sentinel network database study., Jmir Public Health Surveill
Ward H, Flower B, Garcia PJ, et al., 2021, Global surveillance, research, and collaboration needed to improve understanding and management of long COVID, The Lancet, Vol:398, ISSN:0140-6736, Pages:2057-2059
Hay AD, Moore M, Taylor J, et al., 2021, Immediate oral versus immediate topical versus delayed oral antibiotics for children with acute otitis media with discharge: the REST three-arm non-inferiority electronic platform-supported RCT Introduction, Health Technology Assessment, Vol:25, ISSN:1366-5278, Pages:1-+