DrBrijeshPatel

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Cardiothoracic

Contact

+44 (0)20 3315 8897brijesh.patel Website

Location

Adult Intensive Care UnitSydney StreetRoyal Brompton Campus

Summary

Dr Brijesh Patel graduated with distinction honours from University College London Medical School where he was also awarded a Sir Edward Meyerstein Foundation Scholarship for best aggregate performance during basic medical sciences (years 1 and 2). He initially trained in general internal medicine at the former Royal Postgraduate Medical School (Hammersmith Hospital) attaining MRCP during this time. He subsequently pursued clinical training in Anaesthesia and Intensive Care Medicine, through Guy’s and St Thomas’ Hospitals.

He was appointed as one of the first NIHR ‘Walport’ Academic Clinical Fellows within the Imperial School of Anaesthesia. During this time he successfully attained a prestigious Wellcome Trust Clinical Research Training Fellowship to undertake a PhD within the department at Imperial College London. His PhD investigated the role of tumour necrosis factor (TNF), long implicated in lung injury pathogenesis, and discovered that TNF-signalling triggers alveolar epithelial dysfunction in experimental lung injury through activation of death signals. He held the prestigious Gold Medal for Research from the Intensive Care Society (UK) in 2011/12 for research undertaken during his PhD studies. He was also awarded institutional and regional prizes for his research. Having completed his PhD, he went on to complete advanced training in Intensive Care Medicine through the Royal Brompton and King’s College Hospitals. In 2014, he was appointed as a NIHR Clinical Lecturer in Anaesthesia and Intensive Care.

He is as an honorary consultant at the Royal Brompton & Harefield adult intensive care units. He has clinical interests in cardiothoracic intensive care and application of extracorporeal life support (ECLS) technologies. He is a member of the ECLS team at Royal Brompton hospital where he leads the ICU research programme.

His current research focuses on the pathophysiology and basic mechanisms of cell death induced organ injury and inflammation within critical care disease states, including ARDS, sepsis and burns. He has particular interests in the optimisation and improvement of translational disease models of critical illness. He is chief investigator of a number of studies examining physiology-based ventilation algorithms to personalise mechanical ventilation during weaning and during the application of adjunctive interventions in ARDS.

He is the an associate editor for the Journal of the Intenisve Care Society (JICS) and chairperson for the research subcommittee for the commisioned UK ECMO network for adults with sever respiratory failure.

He has been funded by the European Commision Horizon 2020 funding scheme, Academy of Medical Sciences (UK), the National Institute of Academic Anaesthesia, the European Society of Intensive Care Medicine and industry.

Research Themes:

Cell death and survival mechanisms within the lung, in particular, in ARDS and primary graft dysfunction post-lung transplantation.
Physiological and biological personalisation for ARDS management.
Cell death mechanisms during ICU acquired muscle wasting.
Mechanisms of failure to wean from mechanical ventilation.
Inflammation and coagulation during extra-corporeal life support.

Publications

Journals

Paul N, Grunow JJ, Rosenthal M, et al.Paul N, Grunow JJ, Rosenthal M, Spies CD, Page VJ, Hanison J, Patel B, Rosenberg A, von Haken R, Pietsch U, Schrag C, Waydhas C, Schellongowski P, Lobmeyr E, Sander M, Piper SK, Conway D, Totzeck A, Weiss B close, 2023, Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial., Neurocrit Care

Kanai M, Andrews SJ, Cordioli M, et al.Kanai M, Andrews SJ, Cordioli M, Stevens C, Neale BM, Daly M, Ganna A, Pathak GA, Iwasaki A, Karjalainen J, Mehtonen J, Pirinen M, Chwialkowska K, Trankiem A, Balaconis MK, Veerapen K, Wolford BN, Ahmad HF, Andrews S, von Hohenstaufen Puoti KA, Boer C, Boua PR, Butler-Laporte G, Cadilla CL, Chwiałkowska K, Colombo F, Douillard V, Dueker N, Dutta AK, El-Sherbiny YM, Eltoukhy MM, Esmaeeli S, Faucon A, Fave M-J, Cadenas IF, Francescatto M, Francioli L, Franke L, Fuentes M, Durán RG, Cabrero DG, Harry EN, Jansen P, Szentpéteri JL, Kaja E, Kanai M, Kirk C, Kousathanas A, Krieger JE, Patel SK, Lemaçon A, Limou S, Lió P, Marouli E, Marttila MM, Medina-Gómez C, Michaeli Y, Migeotte I, Mondal S, Moreno-Estrada A, Moya L, Nakanishi T, Nasir J, Pasko D, Pearson NM, Pereira AC, Priest J, Prijatelj V, Prokić I, Teumer A, Várnai R, Romero-Gómez M, Roos C, Rosenfeld J, Ruolin L, Schulte EC, Schurmann C, Sedaghati-khayat B, Shaheen D, Shivanathan I, Sipeky C, Sirui Z, Striano P, Tanigawa Y, Remesal AU, Vadgama N, Vallerga CL, van der Laan S, Verdugo RA, Wang QS, Wei Z, Zainulabid UA, Zárate RN, Auton A, Shelton JF, Shastri AJ, Weldon CH, Filshtein-Sonmez T, Coker D, Symons A, Aslibekyan S, O’Connell J, Ye C, Hatoum AS, Agrawal A, Bogdan R, Colbert SMC, Thompson WK, Fan CC, Johnson EC, Niazyan L, Davidyants M, Arakelyan A, Avetyan D, Bekbossynova M, Tauekelova A, Tuleutayev M, Sailybayeva A, Ramankulov Y, Zholdybayeva E, Dzharmukhanov J, Kassymbek K, Tsechoeva T, Turebayeva G, Smagulova Z, Muratov T, Khamitov S, Kwong ASF, Timpson NJ, Niemi MEK, Rahmouni S, Guntz J, Beguin Y, Cordioli M, Pigazzini S, Nkambule L, Georges M, Moutschen M, Misset B, Darcis G, Gofflot S, Bouysran Y, Busson A, Peyrassol X, Wilkin F, Pichon B, Smits G, Vandernoot I, Goffard J-C, Tiembe N, Morrison DR, Afilalo J, Mooser V, Richards JB, Rousseau S, Durand M, Butler-Laporte G, Forgetta V, Laurent L, Afrasiabi Z, Bouab M, Tselios C, Xue X, Afilalo M, Oliveira M, St-Cyr J, Boisclair A, Ragoussis J, Auld D, Kauf close, 2023, A second update on mapping the human genetic architecture of COVID-19, Nature, Vol:621, ISSN:0028-0836, Pages:E7-E26

Jackson C, Stewart ID, Plekhanova T, et al.Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho L-P, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD-C, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF, PHOSP-COVID Study Collaborative Group close, 2023, Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study, The Lancet Respiratory Medicine, Vol:11, ISSN:2213-2600, Pages:673-684

Patel BV, Lee T, O'Dea K, 2023, CLUSTERINg circulating histones in sepsis, American Journal of Respiratory and Critical Care Medicine, Vol:208, ISSN:1073-449X, Pages:125-127

Jenkins TO, MacBean V, Poulsen MK, et al.Jenkins TO, MacBean V, Poulsen MK, Karbing DS, Rees SE, Patel BV, Polkey MI close, 2023, The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care., Intensive Care Medicine Experimental, Vol:11, ISSN:2197-425X, Pages:1-14

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