Imperial College London
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DrBrijeshPatel

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Cardiothoracic
 
 
 
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Contact

 

+44 (0)20 3315 8897brijesh.patel Website

 
 
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Location

 

Adult Intensive Care UnitSydney StreetRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bos:2022:10.1186/s40635-022-00435-w,
author = {Bos, LDJ and Laffey, JG and Ware, LB and Heijnen, NFL and Sinha, P and Patel, B and Jabaudon, M and Bastarache, JA and McAuley, DF and Summers, C and Calfee, CS and Shankar-Hari, M},
doi = {10.1186/s40635-022-00435-w},
journal = {Intensive Care Medicine Experimental},
pages = {1--14},
title = {Towards a biological definition of ARDS: are treatable traits the solution?},
url = {http://dx.doi.org/10.1186/s40635-022-00435-w},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial areas of the lung, variable degrees of epithelial injury, variable degrees of endothelial barrier disruption, transmigration of leukocytes, alongside impaired fluid and ion clearance. These pathophysiological features are different between patients contributing to substantial biological heterogeneity. In this context, it is perhaps unsurprising that a wide range of pharmacological interventions targeting these pathophysiological processes have failed to improve patient outcomes. In this manuscript, our goal is to provide a narrative summary of the potential methods to capture the underlying biological heterogeneity of ARDS and discuss how this information could inform future ARDS redefinitions. We discuss what biological tests are available to identify patients with any of the following predominant biological patterns: (1) epithelial and/or endothelial injury, (2) protein rich pulmonary edema and (3) systemic or within lung inflammatory responses.
AU  - Bos,LDJ
AU  - Laffey,JG
AU  - Ware,LB
AU  - Heijnen,NFL
AU  - Sinha,P
AU  - Patel,B
AU  - Jabaudon,M
AU  - Bastarache,JA
AU  - McAuley,DF
AU  - Summers,C
AU  - Calfee,CS
AU  - Shankar-Hari,M
DO  - 10.1186/s40635-022-00435-w
EP  - 14
PY  - 2022///
SN  - 2197-425X
SP  - 1
TI  - Towards a biological definition of ARDS: are treatable traits the solution?
T2  - Intensive Care Medicine Experimental
UR  - http://dx.doi.org/10.1186/s40635-022-00435-w
UR  - https://icm-experimental.springeropen.com/articles/10.1186/s40635-022-00435-w
UR  - http://hdl.handle.net/10044/1/95901
VL  - 10
ER  -
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