Imperial College London

DrBrynOwen

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer in Endocrinology & Investigative Medic
 
 
 
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Contact

 

bryn.owen05

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Summary

Dr Bryn Owen is a molecular endocrinologist with training in nuclear hormone receptor (NR) signalling. He uses model systems to understand the adaptive processes that maintain whole-body energy homeostasis, and reproductive function, during periods of fluctuating nutrient availability. His lab is investigating how the cellular receptor for estrogen (ER-alpha) in the hypothalamus controls the timing and progression of the ovulatory cycle. He is particularly interested in how this control is lost during nutritional challenges such as anorexia and obesity. He is developing novel transgenic, proteomic, and in vitro systems to answer this question. Dr Owen is also interested in the hypothalamic pathways responsible for the reward-value of nutrient, and the thermogenic potential of the brown adipose tissue (BAT) as a target for anti-obesity therapies.

Dr Owen leads Teaching and Assessment for the BSc in Endocrinology, co-chairs the College-wide 3Rs advisory group, and sits on the Department’s Athena SWAN committee.

Publications

Journals

Yang L, Demetriou L, Wall M, et al., 2020, Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men, Jci Insight, Vol:5, ISSN:2379-3708

Fernandes-Freitas I, Milona A, Murphy KG, et al., 2020, Live birth in sex-reversed XY mice lacking the nuclear receptor Dax1, Scientific Reports, Vol:10, ISSN:2045-2322

Milona A, Massafra V, Vos H, et al., 2019, Steroidogenic control of liver metabolism through a nuclear receptor-network, Molecular Metabolism, Vol:30, ISSN:2212-8778, Pages:221-229

Jones B, Buenaventura T, Kanda N, et al., 2018, Targeting GLP-1 receptor trafficking to improve agonist efficacy, Nature Communications, Vol:9, ISSN:2041-1723

Owen BM, Sondhi V, Liu J, et al., 2016, Impaired 17,20-lyase activity in male mice lacking cytochrome b5 in Leydig cells, Molecular Endocrinology, Vol:30, ISSN:1944-9917, Pages:469-478

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