Imperial College London
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DrBrynOwen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

bryn.owen05

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Owen:2014:10.1016/j.cmet.2014.07.012,
author = {Owen, BM and Ding, X and Morgan, DA and Coate, KC and Bookout, AL and Rahmouni, K and Kliewer, SA and Mangelsdorf, DJ},
doi = {10.1016/j.cmet.2014.07.012},
journal = {Cell Metabolism},
pages = {670--677},
title = {FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss},
url = {http://dx.doi.org/10.1016/j.cmet.2014.07.012},
volume = {20},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mice, we show that βKlotho, the obligate coreceptor for FGF21, is required in the nervous system for these effects. FGF21 stimulates sympathetic nerve activity to brown adipose tissue through a mechanism that depends on the neuropeptide corticotropin-releasing factor. Our findings provide an unexpected mechanistic explanation for the strong pharmacologic effects of FGF21 on energy expenditure and weight loss in obese animals.
AU  - Owen,BM
AU  - Ding,X
AU  - Morgan,DA
AU  - Coate,KC
AU  - Bookout,AL
AU  - Rahmouni,K
AU  - Kliewer,SA
AU  - Mangelsdorf,DJ
DO  - 10.1016/j.cmet.2014.07.012
EP  - 677
PY  - 2014///
SN  - 1550-4131
SP  - 670
TI  - FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2014.07.012
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343586500016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1550413114003209?via%3Dihub
VL  - 20
ER  -
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