Imperial College London
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DrBrynOwen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

bryn.owen05

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Talukdar:2016:10.1016/j.cmet.2015.12.008,
author = {Talukdar, S and Owen, BM and Song, P and Hernandez, G and Zhang, Y and Zhou, Y and Scott, WT and Paratala, B and Turner, T and Smith, A and Bernardo, B and Müller, CP and Tang, H and Mangelsdorf, DJ and Goodwin, B and Kliewer, SA},
doi = {10.1016/j.cmet.2015.12.008},
journal = {Cell Metabolism},
pages = {344--349},
title = {FGF21 regulates sweet and alcohol preference},
url = {http://dx.doi.org/10.1016/j.cmet.2015.12.008},
volume = {23},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.
AU  - Talukdar,S
AU  - Owen,BM
AU  - Song,P
AU  - Hernandez,G
AU  - Zhang,Y
AU  - Zhou,Y
AU  - Scott,WT
AU  - Paratala,B
AU  - Turner,T
AU  - Smith,A
AU  - Bernardo,B
AU  - Müller,CP
AU  - Tang,H
AU  - Mangelsdorf,DJ
AU  - Goodwin,B
AU  - Kliewer,SA
DO  - 10.1016/j.cmet.2015.12.008
EP  - 349
PY  - 2016///
SN  - 1932-7420
SP  - 344
TI  - FGF21 regulates sweet and alcohol preference
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2015.12.008
VL  - 23
ER  -
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