Publications

BibTex format

@inbook{Muhieddine:2022:10.1016/B978-0-323-85159-6.50360-2,
author = {Muhieddine, MH and Viswanath, SK and Armstrong, A and Galindo, A and Adjiman, CS},
booktitle = {Computer Aided Chemical Engineering},
doi = {10.1016/B978-0-323-85159-6.50360-2},
pages = {2161--2166},
title = {Multi-objective optimisation for early-stage pharmaceutical process development},
url = {http://dx.doi.org/10.1016/B978-0-323-85159-6.50360-2},
year = {2022}
}

Download

RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The pharmaceutical industry is under constant pressure to deliver its products quickly and effectively while minimising development costs and pursuing green pharmaceutical manufacturing methods. Given the many considerations in process development, a model-based method that takes multiple performance metrics into account is proposed for early process development. Several key performance indicators are identified, namely environmental footprint, cost, and conversion, selectivity, and yield. We employ multi-objective optimisation to assess the trade-offs between capital cost as one objective, and selectivity or conversion as a second objective, while exploring the interdependencies between all performance indicators. The approach is applied to two multiphasic reactions, each occurring in a 6-stage cascade CSTR: the hydrogenation of 4-Isobutylacetophenone (4-IBAP) to 1-(4-Isobutylphenyl) ethanol (4-IBPE) and the carbonylation of 4-IBPE to Ibuprofen (IBP).
AU  - Muhieddine,MH
AU  - Viswanath,SK
AU  - Armstrong,A
AU  - Galindo,A
AU  - Adjiman,CS
DO  - 10.1016/B978-0-323-85159-6.50360-2
EP  - 2166
PY  - 2022///
SP  - 2161
TI  - Multi-objective optimisation for early-stage pharmaceutical process development
T1  - Computer Aided Chemical Engineering
UR  - http://dx.doi.org/10.1016/B978-0-323-85159-6.50360-2
ER  -

Download

Prof Claire S. Adjiman FREng

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)