Dr Aylett’s team works on the molecular pathways controlling cell growth. The aim of his research is to understand how different types of cells make the decision to grow or not to grow in response to their environment at a molecular level.
These processes are controlled by the assembly of signalling complexes that can only be visualised through X-ray crystallography and electron cryo-microscopy, and therefore Dr Aylett is also engaged in developing new techniques for sample preparation and analysis in these fields.
Understanding these pathways will have important benefits for many diverse human diseases; from diseases of dysfunction, such as cancer and diabetes, to direct infections by bacteria or viruses.
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et al., 2021, Direct transfer of electron microscopy samples to wetted carbon and graphene films via a support floatation block (vol 213, 107677, 2021), Journal of Structural Biology, Vol:213, ISSN:1047-8477
et al., 2021, Structure of the bacteriophage PhiKZ non-virion RNA polymerase, Nucleic Acids Research, Vol:49, ISSN:0305-1048, Pages:7732-7739
Aylett C, de Martin Garrido N, Ramlaul K, 2021, Preparation of sample support films in transmission electron microscopy using a support floatation block, Jove-journal of Visualized Experiments, Vol:170, ISSN:1940-087X, Pages:1-11
et al., 2021, Architecture of the Tuberous Sclerosis protein complex, Journal of Molecular Biology, Vol:433, ISSN:0022-2836