Dr Aylett’s team works on the molecular pathways controlling cell growth. The aim of his research is to understand how different types of cells make the decision to grow or not to grow in response to their environment at a molecular level.
These processes are controlled by the assembly of signalling complexes that can only be visualised through X-ray crystallography and electron cryo-microscopy, and therefore Dr Aylett is also engaged in developing new techniques for sample preparation and analysis in these fields.
Understanding these pathways will have important benefits for many diverse human diseases; from diseases of dysfunction, such as cancer and diabetes, to direct infections by bacteria or viruses.
Aylett C, 2020, Architecture of the Tuberous Sclerosis Protein Complex, Journal of Molecular Biology, ISSN:0022-2836
Aylett C, 2020, Direct transfer of electron microscopy samples to wetted carbon and graphene films via a support floatation block, Journal of Structural Biology, ISSN:1047-8477
et al., 2020, Mitigating local over-fitting during single particle reconstruction with SIDESPLITTER, Journal of Structural Biology, Vol:211, ISSN:1047-8477, Pages:1-9
de Martin Garrido N, Aylett C, 2020, Nutrient signalling and lysosome positioning crosstalk through a multifunctional protein, Folliculin, Frontiers in Cell and Developmental Biology, Vol:8, ISSN:2296-634X
et al., 2020, Bacteriophage MS2 displays unreported capsid variability assembling T = 4 and mixed capsids, Molecular Microbiology, Vol:113, ISSN:0950-382X, Pages:143-152