Summary
Dr Aylett’s team works on the molecular pathways controlling cell growth. The aim of his research is to understand how different types of cells make the decision to grow or not to grow in response to their environment at a molecular level.
These processes are controlled by the assembly of signalling complexes that can only be visualised through X-ray crystallography and electron cryo-microscopy, and therefore Dr Aylett is also engaged in developing new techniques for sample preparation and analysis in these fields.
Understanding these pathways will have important benefits for many diverse human diseases; from diseases of dysfunction, such as cancer and diabetes, to direct infections by bacteria or viruses.
Publications
Journals
Ramlaul K, Feng Z, Canavan C, et al., 2023, A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate, Journal of Structural Biology, Vol:215, ISSN:1047-8477, Pages:1-12
Palmer CM, Aylett CHS, 2022, Real space in cryo-EM: the future is local., Acta Crystallographica Section D: Structural Biology, Vol:78, ISSN:0907-4449, Pages:136-143
Garrido NDM, Orekhova M, Loong YTELW, et al., 2021, Structure of the bacteriophage PhiKZ non-virion RNA polymerase (vol 49, pg 7732, 2021), Nucleic Acids Research, Vol:49, ISSN:0305-1048, Pages:10806-10806
Garrido NDM, Fu W, Ramlaul K, et al., 2021, Direct transfer of electron microscopy samples to wetted carbon and graphene films via a support floatation block (vol 213, 107677, 2021), Journal of Structural Biology, Vol:213, ISSN:1047-8477, Pages:1-2
deYMartín Garrido N, Orekhova M, Lai Wan Loong YTE, et al., 2021, Structure of the bacteriophage PhiKZ non-virion RNA polymerase, Nucleic Acids Research, Vol:49, ISSN:0305-1048, Pages:7732-7739