Imperial College London
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DrChristopherAylett

Faculty of Medicine, Department of Infectious Disease

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3862c.aylett

 
 
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Location

 

6.40bFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Aylett:2015:10.1038/nsmb.2963,
author = {Aylett, CHS and Boehringer, D and Erzberger, JP and Schaefer, T and Ban, N},
doi = {10.1038/nsmb.2963},
journal = {Nat Struct Mol Biol},
pages = {269--271},
title = {Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex.},
url = {http://dx.doi.org/10.1038/nsmb.2963},
volume = {22},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences in initiation-complex binding to the ribosome compared to that of mammalian eIF3, demonstrates a direct contact between eIF3j and eIF1A and reveals the network of interactions between eIF3 subunits.
AU  - Aylett,CHS
AU  - Boehringer,D
AU  - Erzberger,JP
AU  - Schaefer,T
AU  - Ban,N
DO  - 10.1038/nsmb.2963
EP  - 271
PY  - 2015///
SP  - 269
TI  - Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex.
T2  - Nat Struct Mol Biol
UR  - http://dx.doi.org/10.1038/nsmb.2963
UR  - https://www.ncbi.nlm.nih.gov/pubmed/25664723
VL  - 22
ER  -
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