Summary
BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
PhD 1987
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
Fellow of the Royal Society 2019
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the virology and immunology of persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I) - see https://doi.org/10.26320/SCIENTIA225
. Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
Publications
Journals
Yaguchi H, Melamed A, Ramanayake S, et al., 2024, The impact of HTLV-1 expression on the 3D structure and expression of host chromatin., Plos Pathog, Vol:20
Maher A, Aristodemou A, Giang N, et al., 2024, HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1-associated myelopathy, Journal of Clinical Investigation Insight, Vol:9, ISSN:0021-9738
Aristodemou AENR, Rueda D, Taylor GR, et al., 2023, The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle, Plos Pathogens, Vol:19, ISSN:1553-7366
Bangham CRM, 2023, HTLV-1 persistence and the oncogenesis of adult T-cell leukemia/lymphoma, Blood, Vol:141, ISSN:0006-4971, Pages:2299-2306
Prawiro C, Bunney TD, Kampyli C, et al., 2023, A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells, Bba: Molecular Basis of Disease, Vol:1869, ISSN:0925-4439