Publications
303 results found
Tattermusch S, Skinner J, Chaussabel D, et al., 2010, An interferon signature is associated with disease but not viral containment in chronic infection with the human T-cell lymphotropic virus type 1, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 188-188, ISSN: 0019-2805
Afonso PV, Mekaouche M, Mortreux F, et al., 2010, Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors, BLOOD, Vol: 116, Pages: 3802-3808, ISSN: 0006-4971
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- Citations: 60
MacNamara A, Rowan A, Hilburn S, et al., 2010, HLA Class I Binding of HBZ Determines Outcome in HTLV-1 Infection, PLOS PATHOGENS, Vol: 6, ISSN: 1553-7366
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- Citations: 107
Cloke TE, Garvey L, Choi B-S, et al., 2010, Increased Level of Arginase Activity Correlates with Disease Severity in HIV-Seropositive Patients, JOURNAL OF INFECTIOUS DISEASES, Vol: 202, Pages: 374-385, ISSN: 0022-1899
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- Citations: 41
Toulza F, Nosaka K, Tanaka Y, et al., 2010, Human T-Lymphotropic Virus Type 1-Induced CC Chemokine Ligand 22 Maintains a High Frequency of Functional FoxP3<SUP>+</SUP> Regulatory T Cells, JOURNAL OF IMMUNOLOGY, Vol: 185, Pages: 183-189, ISSN: 0022-1767
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- Citations: 50
Nejmeddine M, Bangham CRM, 2010, The HTLV-1 Virological Synapse, VIRUSES-BASEL, Vol: 2, Pages: 1427-1447, ISSN: 1999-4915
Toulza F, Nosaka K, Takiguchi M, et al., 2009, FoxP3+regulatory T cells are distinct from leukemia cells in HTLV- I -associated adult T-cell leukemia, INTERNATIONAL JOURNAL OF CANCER, Vol: 125, Pages: 2375-2382, ISSN: 0020-7136
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- Citations: 46
Hlela C, Bangham CR, Graham OGG, et al., 2009, South African individuals with Human T-Lymphotropic Virus Type 1 (HTLV-1) Associated Infective Dermatitis do not have an Atopic Diathesis, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1279-1279, ISSN: 0889-2229
Gillet N, Melamed A, Bangham C, et al., 2009, Development of a New Technique Using High-Throughput Sequencing to Determine the HLTV Clonality, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1235-1235, ISSN: 0889-2229
Nejmeddine M, Lewis PN, Majorovits E, et al., 2009, HTLV-1 Virological Synapse: Ultrastructure and Role of Tax Protein, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1225-1225, ISSN: 0889-2229
Rowan A, Macnamara A, Asquith B, et al., 2009, Sensitivity and Efficiency of HTLV-1-Specific Cytotoxic T Lymphocytes, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1286-1287, ISSN: 0889-2229
Macnamara A, Rowan A, Asquith B, et al., 2009, HLA Class I Binding of HBZ is Associated with Reduced HTLV-I Proviral Load and HAM/TSP Prevalence, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1258-1259, ISSN: 0889-2229
Ferreira AF, Rowan A, Bangham CR, et al., 2009, Quantification of CD8+ T Cell Responses to HTLV-1: Balance of inflammatory and Antiviral Effects, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1286-1286, ISSN: 0889-2229
Tattermusch S, Bangham C, Chaussabel D, et al., 2009, The HTLV-1 Immune Signature: Identification of an HTLV-1 Specific Transcriptional Fingerprint by Microarray, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1287-1287, ISSN: 0889-2229
MacNamara A, Rowan A, Kadolsky U, et al., 2009, HBZ Binding to HLA Class 1 Determines the Outcome of HTLV-1, 14th International Conference on Human Retrovirology HTLV and Related Retroviruses, Publisher: MARY ANN LIEBERT INC, Pages: 1201-1202, ISSN: 0889-2229
Nejmeddine M, Negi VS, Mukherjee S, et al., 2009, HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse, BLOOD, Vol: 114, Pages: 1016-1025, ISSN: 0006-4971
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- Citations: 75
Modolell M, Choi B-S, Ryan RO, et al., 2009, Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis, PLOS NEGLECTED TROPICAL DISEASES, Vol: 3, ISSN: 1935-2735
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- Citations: 79
Bangham CRM, 2009, CTL quality and the control of human retroviral infections, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 39, Pages: 1700-1712, ISSN: 0014-2980
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- Citations: 108
Lezin A, Olindo S, Belrose G, et al., 2009, Gene activation therapy: from the BLV model to HAM/TSP patients., Front Biosci (Schol Ed), Vol: 1, Pages: 205-215
HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dynamic kinetics resulting in equilibrium between the virus, which attempts to proliferate, and the immune response, which seeks to exert tight control of the virus. A major determinant of disease induction by both viruses is the accumulation of provirus in peripheral blood. In the absence of viral proteins, virus infected cells escape recognition and destruction by the host immune response. We propose a novel therapeutic strategy based on transient activation of viral expression using epigenetic modulators; this exposes infected cells to the immune response and results in significant reductions in proviral loads. In the absence of satisfactory therapies, this viral gene-activation strategy might delay progression, or even be curative, for HTLV-1 induced myelopathy / tropical spastic paraparesis (HAM/TSP).
Kattan T, MacNamara A, Rowan AG, et al., 2009, The Avidity and Lytic Efficiency of the CTL Response to HTLV-1, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 5723-5729, ISSN: 0022-1767
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- Citations: 48
Mosley AJ, Bangham CRM, 2009, A new hypothesis for the pathogenesis of Human T-lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis, Bioscience Hypotheses, Vol: 2, Pages: 118-124, ISSN: 1756-2392
The exogenous, human retrovirus Human T-lymphotropic virus type 1 (HTLV-1) results in a highly dynamic persistent infection. HTLV-1 usually causes an asymptomatic infection but a small proportion of individuals may develop HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic inflammatory disease of the central nervous system (CNS) that is rarely fatal, but can be severely debilitating. HTLV-1 is found in the CNS primarily within infiltrating, infected CD4+ T lymphocytes. CD4+ T-cell infiltration into the CNS is currently believed to be the pivotal event for the pathogenesis of HAM/TSP but the exact mechanisms by which these T cells result in neurological damage are unknown. Here we explore a current hypothesis of HAM/TSP pathogenesis and suggest a new hypothesis focused on why the majority of HTLV-1-infected individuals do not develop neuroinflammatory disease. In this new hypothesis we highlight the two battles for control over HTLV-1 activity that occur in the peripheral blood and the CNS. We also introduce the idea that HAM/TSP is the result of a disturbed damage:healing ratio within the spinal cord that is dependent on the activity of HTLV-1 proteins, glia and infiltrating immune cells. © 2009 Elsevier Ltd. All rights reserved.
MacNamara A, Kadolsky U, Bangham CRM, et al., 2009, T-Cell Epitope Prediction: Rescaling Can Mask Biological Variation between MHC Molecules, PLOS COMPUTATIONAL BIOLOGY, Vol: 5
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- Citations: 25
Bangham CRM, Meekings K, Toulza F, et al., 2009, The immune control of HTLV-1 infection: selection forces and dynamics, FRONTIERS IN BIOSCIENCE-LANDMARK, Vol: 14, Pages: 2889-2903, ISSN: 2768-6701
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- Citations: 39
Bangham CRM, 2008, HTLV-1 infection: role of CTL efficiency, BLOOD, Vol: 112, Pages: 2176-2177, ISSN: 0006-4971
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- Citations: 21
Toulza F, Heaps A, Tanaka Y, et al., 2008, High frequency of CD4<SUP>+</SUP>FoxP3<SUP>+</SUP> cells in HTLV-1 infection:: inverse correlation with HTLV-1-specific CTL response, BLOOD, Vol: 111, Pages: 5047-5053, ISSN: 0006-4971
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- Citations: 97
Pichler K, Kattan T, Gentzsch J, et al., 2008, Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral tax oncoprotein, BLOOD, Vol: 111, Pages: 4741-4751, ISSN: 0006-4971
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- Citations: 30
Meekings KN, Leipzig J, Bushman FD, et al., 2008, HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366
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- Citations: 82
Asquith B, Bangharn CRM, 2008, How does HTLV-I persist despite a strong cell-mediated immune response?, TRENDS IN IMMUNOLOGY, Vol: 29, Pages: 4-11, ISSN: 1471-4906
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- Citations: 46
Mosley AJ, Bangham CRM, 2008, Human T-lymphotropic virus type 1 and disease in the central nervous system, NEUROTROPIC VIRAL INFECTIONS, Editors: Reiss, Publisher: CAMBRIDGE UNIV PRESS, Pages: 141-166
Majorovits E, Nejmeddine M, Tanaka Y, et al., 2008, Human T-lymphotropic virus-1 visualized at the virological synapse by electron tomography, PLOS One, Vol: 3
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