Imperial College London
Alternate

ProfessorCharlesBangham

Institute of Infection

Co-Director of the Institute of Infection
 
 
 
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Contact

 

+44 (0)20 7594 3730c.bangham Website

 
 
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Assistant

 

Ms Linda Hollick +44 (0)20 7594 3729

 
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Location

 

115Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bangham:2018:10.7554/eLife.36245,
author = {Bangham, CRM and Melamed, A and Yaguchi, H and Miura, M and Witkover, A and Fitzgerald, T and Birney, E},
doi = {10.7554/eLife.36245},
journal = {eLife},
pages = {1--20},
title = {The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis},
url = {http://dx.doi.org/10.7554/eLife.36245},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact on the structure and expression of host chromatin by the human retrovirus HTLV-1. We show that HTLV-1 disrupts host chromatin structure by forming loops between the provirus and the host genome; certain loops depend on the critical chromatin architectural protein CTCF, which we recently discovered binds to the HTLV-1 provirus. We show that the provirus causes two distinct patterns of abnormal transcription of the host genome in cis: bidirectional transcription in the host genome immediately flanking the provirus, and clone-specific transcription in cis at non-contiguous loci up to >300 kb from the integration site. We conclude that HTLV-1 causes insertional mutagenesis up to the megabase range in the host genome in >104 persistently-maintained HTLV-1+ T-cell clones in vivo.
AU  - Bangham,CRM
AU  - Melamed,A
AU  - Yaguchi,H
AU  - Miura,M
AU  - Witkover,A
AU  - Fitzgerald,T
AU  - Birney,E
DO  - 10.7554/eLife.36245
EP  - 20
PY  - 2018///
SN  - 2050-084X
SP  - 1
TI  - The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.36245
UR  - https://elifesciences.org/articles/36245
UR  - http://hdl.handle.net/10044/1/61147
VL  - 7
ER  -
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