Imperial College London
Alternate

ProfessorCharlesBangham

Institute of Infection

Co-Director of the Institute of Infection
 
 
 
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Contact

 

+44 (0)20 7594 3730c.bangham Website

 
 
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Assistant

 

Ms Linda Hollick +44 (0)20 7594 3729

 
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Location

 

115Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Araujo:2020:10.1212/CPJ.0000000000000832,
author = {Araujo, A and Bangham, CRM and Casseb, J and Gotuzzo, E and Jacobson, S and Martin, F and Oliviera, AP and Puccioni-Sohler, M and Taylor, GP and Yamano, Y},
doi = {10.1212/CPJ.0000000000000832},
journal = {Neurology: Clinical Practice},
pages = {49--56},
title = {The management of HAM/TSP: Systematic review and consensus-based recommendations 2019},
url = {http://dx.doi.org/10.1212/CPJ.0000000000000832},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose of Review: To provide an evidence-based approach to the use of therapies that are prescribed to improve the natural history of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) – a rare disease.Recent Findings: All 41 articles on the clinical outcome of disease-modifying therapy for HAM/TSP were included in a systematic review by members of the International Retrovirology Association; we report here the consensus assessment and recommendations. The quality of available evidence is low, being based for the most part on observational studies, with only one double-masked placebo-controlled randomised trial. Summary: There is evidence to support the use of both high-dose pulsed methyl prednisolone for induction and low-dose (5mg) oral prednisolone as maintenance therapy for progressive disease. There is no evidence to support the use of antiretroviral therapy. There is insufficient evidence to support the use of interferon-α as a first-line therapy.
AU  - Araujo,A
AU  - Bangham,CRM
AU  - Casseb,J
AU  - Gotuzzo,E
AU  - Jacobson,S
AU  - Martin,F
AU  - Oliviera,AP
AU  - Puccioni-Sohler,M
AU  - Taylor,GP
AU  - Yamano,Y
DO  - 10.1212/CPJ.0000000000000832
EP  - 56
PY  - 2020///
SN  - 2163-0402
SP  - 49
TI  - The management of HAM/TSP: Systematic review and consensus-based recommendations 2019
T2  - Neurology: Clinical Practice
UR  - http://dx.doi.org/10.1212/CPJ.0000000000000832
UR  - https://cp.neurology.org/content/11/1/49/
UR  - http://hdl.handle.net/10044/1/75598
VL  - 11
ER  -
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