Imperial College London
Alternate

ProfessorCharlesBangham

Institute of Infection

Co-Director of the Institute of Infection
 
 
 
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Contact

 

+44 (0)20 7594 3730c.bangham Website

 
 
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Assistant

 

Ms Linda Hollick +44 (0)20 7594 3729

 
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Location

 

115Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kagdi:2016:10.1002/cam4.928,
author = {Kagdi, HH and taylor, GPT and DEMONTIS, MA and BANGHAM, CR and Fields, P and Carlos, JC},
doi = {10.1002/cam4.928},
journal = {Cancer Medicine},
pages = {298--309},
title = {Risk stratification of adult T cell leukemia/lymphoma using immunophenotyping},
url = {http://dx.doi.org/10.1002/cam4.928},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Adult T cell leukemia/lymphoma (ATL), a human T lymphotropic virus type 1 (HTLV-1) –associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and non-malignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication.  To further refine the diagnosis and prognosis of ATL we characterized the immunophenotype of HTLV-1-infected cells in ATL and non-ATL.  A retrospective study of peripheral blood samples from ten HTLV-1-uninfected subjects (UI), 54 HTLV-1infected patients with non-ATL and 22 with ATL was performed using flow cytometry.  All patients with ATL had CD4+CCR4+CD26- immunophenotype and the frequency of CD4+CCR4+CD26- T cells correlated highly significantly with the proviral load in non-ATL suggesting CD4+CCR4+CD26- as a marker of HTLV-1 infected cells. Further immunophenotyping of CD4+CCR4+CD26- cells revealed that 95% patients with ATL had a CD7- (≤ 30% CD7+ cells) whereas 95% HTLV+ non-ATL had CD7+ (>30% CD7+ cells) immunophenotype.  All patients with aggressive ATL had a CCR7+ (≥30%), whereas 92 % with indolent ATL and 100% non-ATL had a CCR7- (<30%) immunophenotype.  Patients with non-progressing indolent ATL were CD127+ but those with progressive lymphocytosis requiring systemic therapy had a CD127- (≤ 30%) immunophenotype. In summary, HTLV-1-infected cells have a CD4+CCR4+CD26- immunophenotype. Within this population, CD7- phenotype suggests a diagnosis of ATL, CCR7+ phenotype identifies aggressive ATL, while CCR7- CD127- phenotype identifies progressive indolent ATL.
AU  - Kagdi,HH
AU  - taylor,GPT
AU  - DEMONTIS,MA
AU  - BANGHAM,CR
AU  - Fields,P
AU  - Carlos,JC
DO  - 10.1002/cam4.928
EP  - 309
PY  - 2016///
SN  - 2045-7634
SP  - 298
TI  - Risk stratification of adult T cell leukemia/lymphoma using immunophenotyping
T2  - Cancer Medicine
UR  - http://dx.doi.org/10.1002/cam4.928
UR  - http://hdl.handle.net/10044/1/40118
VL  - 6
ER  -
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