Imperial College London
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DrCherylBattersby

Faculty of Medicine, School of Public Health

Clinical Senior Lecturer in Neonatal Medicine
 
 
 
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Contact

 

+44 (0)20 3315 3047c.battersby Website

 
 
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Location

 

G.4.4.Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rees:2022:10.1542/peds.2022-057442,
author = {Rees, P and Callan, C and Chadda, K and Vaal, M and Diviney, J and Sabti, S and Harnden, F and Gardiner, J and Battersby, C and Gale, C and Sutcliffe, A},
doi = {10.1542/peds.2022-057442},
journal = {Pediatrics},
pages = {1--15},
title = {Preterm brain injury and neurodevelopmental outcomes: a meta-analysis},
url = {http://dx.doi.org/10.1542/peds.2022-057442},
volume = {150},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Context:Preterm brain injuries are common; neurodevelopmental outcomes following contemporary neonatal care are continually evolving.Objective:To systematically review and meta-analyze neurodevelopmental outcomes among preterm infants after intraventricular hemorrhage (IVH) and white matter injury (WMI). Data Sources:Published and grey literature were searched across 10 databases between 2000-2021Study Selection:Observational studies reporting 3-year neurodevelopmental outcomes for preterm infants with IVH or WMI compared to preterm infants without injury.Data extraction:Study characteristics, population characteristics, and outcome data were extracted.Results:38 studies were included. There was an increased adjusted risk of moderate-severe neurodevelopmental impairment after IVH grade 1-2 (aOR 1.35 [95% CI 1.05, 1.75]) and IVH grade 3-4 (aOR 4.26 [3.25, 5.59]). Children with IVH grade 1-2 had higher risks of cerebral palsy (OR 1.76 [1.39, 2.24)], cognitive (OR 1.79 [1.09, 2.95]), hearing (OR 1.83 CI [1.03. 3.24]), and visual impairment (OR 1.77 [1.08, 2.9]). Children with IVH grade 3-4 had markedly higher risks of cerebral palsy (OR 4.98 [4.13, 6.00)], motor (OR 2.7 [1.52, 4.8)], cognitive (OR 2.3 [1.67, 3.15)], hearing (OR 2.44 [1.42, 4.2)), and visual impairment (OR 5.42 [2.77, 10.58)). Children with WMI had much higher risks of cerebral palsy (OR 14.91 [7.3, 30.46), motor (OR 5.3 [3, 9.36)], and cognitive impairment (OR 3.48 [2.18, 5.53)).Limitations:Heterogeneity of outcome data.Conclusions:Mild IVH, severe IVH, and WMI are associated with adverse neurodevelopmental outcomes. Utilization of core outcomes sets and availability of open-access study data would improve our understanding of the nuances of these outcomes.
AU  - Rees,P
AU  - Callan,C
AU  - Chadda,K
AU  - Vaal,M
AU  - Diviney,J
AU  - Sabti,S
AU  - Harnden,F
AU  - Gardiner,J
AU  - Battersby,C
AU  - Gale,C
AU  - Sutcliffe,A
DO  - 10.1542/peds.2022-057442
EP  - 15
PY  - 2022///
SN  - 0031-4005
SP  - 1
TI  - Preterm brain injury and neurodevelopmental outcomes: a meta-analysis
T2  - Pediatrics
UR  - http://dx.doi.org/10.1542/peds.2022-057442
UR  - https://publications.aap.org/pediatrics/article/150/6/e2022057442/189905/Preterm-Brain-Injury-and-Neurodevelopmental?autologincheck=redirected
UR  - http://hdl.handle.net/10044/1/99795
VL  - 150
ER  -
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