Publications

BibTex format

@article{Battersby:2016:10.1016/S2468-1253(16)30117-0,
author = {Battersby, CWS and Longford, N and Mandalia, S and Costeloe, K and Modi, N},
doi = {10.1016/S2468-1253(16)30117-0},
journal = {Lancet Gastroenterology and Hepatology},
pages = {43--51},
title = {Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study},
url = {http://dx.doi.org/10.1016/S2468-1253(16)30117-0},
volume = {2},
year = {2016}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundNecrotising enterocolitis is a neonatal gastrointestinal inflammatory disease with high mortality and severe morbidity. This disorder is growing in global relevance as birth rates and survival of babies with low gestational age improve. Population data are scant and pathogenesis is incompletely understood, but enteral feed exposures are believed to affect risk. We aimed to quantify the national incidence of severe necrotising enterocolitis, describe variation across neonatal networks, and investigate enteral feeding-related antecedents of severe necrotising enterocolitis.MethodsWe undertook a 2-year national surveillance study (the UK Neonatal Collaborative Necrotising Enterocolitis [UKNC-NEC] Study) of babies born in England to quantify the burden of severe or fatal necrotising enterocolitis confirmed by laparotomy, leading to death, or both. Data on all liveborn babies admitted to neonatal units between Jan 1, 2012, and Dec 31, 2013, were obtained from the National Neonatal Research Database. In the subgroup of babies born before a gestational age of 32 weeks, we did a propensity score analysis of the effect of feeding in the first 14 postnatal days with own mother’s milk, with or without human donor milk and avoidance of bovine-origin formula, or milk fortifier, on the risk of developing necrotising enterocolitis.FindingsDuring the study period, 118073 babies were admitted to 163 neonatal units across 23 networks, of whom 14678 were born before a gestational age of 32 weeks. Overall, 531 (0·4%) babies developed severe necrotising enterocolitis, of whom 247 (46·5%) died (139 after laparotomy). 462 (3·2%) of 14678 babies born before a gestational age of 32 weeks developed severe necrotising enterocolitis, of whom 222 (48·1%) died. Among babies born before a gestational age of 32 weeks, the adjusted network incidence of necrotising enterocolitis ranged from 2·51% (95% CI 1·13–3·60) to 3·
AU  - Battersby,CWS
AU  - Longford,N
AU  - Mandalia,S
AU  - Costeloe,K
AU  - Modi,N
DO  - 10.1016/S2468-1253(16)30117-0
EP  - 51
PY  - 2016///
SN  - 2468-1253
SP  - 43
TI  - Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study
T2  - Lancet Gastroenterology and Hepatology
UR  - http://dx.doi.org/10.1016/S2468-1253(16)30117-0
UR  - http://hdl.handle.net/10044/1/43244
VL  - 2
ER  -

Download

DrCherylBattersby

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)