Imperial College London
Alternate

Professor Chris Braddock

Faculty of Natural Sciences, Department of Chemistry

Professor of Organic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5772c.braddock

 
 
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Location

 

601EMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Braddock:2022:10.1021/acs.orglett.1c04265,
author = {Braddock, D and Davies, J and Lickiss, P},
doi = {10.1021/acs.orglett.1c04265},
journal = {Organic Letters},
pages = {1175--1179},
title = {Methyltrimethoxysilane (MTM) as a reagent for direct amidation of carboxylic acids},
url = {http://dx.doi.org/10.1021/acs.orglett.1c04265},
volume = {24},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Methyltrimethoxysilane [MTM, CH3Si(OMe)3] has been demonstrated to be an effective, inexpensive, and safe reagent for the direct amidation of carboxylic acids with amines. Two simple workup procedures that provide the pure amide product without the need for further purification have been developed. The first employs an aqueous base-mediated annihilation of MTM. The second involves simple product crystallization from the reaction mixture providing a low process mass intensity direct amidation protocol.
AU  - Braddock,D
AU  - Davies,J
AU  - Lickiss,P
DO  - 10.1021/acs.orglett.1c04265
EP  - 1179
PY  - 2022///
SN  - 1523-7052
SP  - 1175
TI  - Methyltrimethoxysilane (MTM) as a reagent for direct amidation of carboxylic acids
T2  - Organic Letters
UR  - http://dx.doi.org/10.1021/acs.orglett.1c04265
UR  - http://hdl.handle.net/10044/1/94935
VL  - 24
ER  -
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